Humanizing the yeast origin recognition complex

In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung, Bik-Kwoon Tye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4ce881c9d4e4808a3ce45ff1501fdd0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4ce881c9d4e4808a3ce45ff1501fdd0
record_format	dspace
spelling	oai:doaj.org-article:f4ce881c9d4e4808a3ce45ff1501fdd02021-12-02T15:08:00ZHumanizing the yeast origin recognition complex10.1038/s41467-020-20277-y2041-1723https://doaj.org/article/f4ce881c9d4e4808a3ce45ff1501fdd02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20277-yhttps://doaj.org/toc/2041-1723In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertion helix in the Orc4 subunit which is lost in human.Clare S. K. LeeMing Fung CheungJinsen LiYongqian ZhaoWai Hei LamVincy HoRemo RohsYuanliang ZhaiDanny LeungBik-Kwoon TyeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye Humanizing the yeast origin recognition complex
description	In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertion helix in the Orc4 subunit which is lost in human.
format	article
author	Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye
author_facet	Clare S. K. Lee Ming Fung Cheung Jinsen Li Yongqian Zhao Wai Hei Lam Vincy Ho Remo Rohs Yuanliang Zhai Danny Leung Bik-Kwoon Tye
author_sort	Clare S. K. Lee
title	Humanizing the yeast origin recognition complex
title_short	Humanizing the yeast origin recognition complex
title_full	Humanizing the yeast origin recognition complex
title_fullStr	Humanizing the yeast origin recognition complex
title_full_unstemmed	Humanizing the yeast origin recognition complex
title_sort	humanizing the yeast origin recognition complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4ce881c9d4e4808a3ce45ff1501fdd0
work_keys_str_mv	AT claresklee humanizingtheyeastoriginrecognitioncomplex AT mingfungcheung humanizingtheyeastoriginrecognitioncomplex AT jinsenli humanizingtheyeastoriginrecognitioncomplex AT yongqianzhao humanizingtheyeastoriginrecognitioncomplex AT waiheilam humanizingtheyeastoriginrecognitioncomplex AT vincyho humanizingtheyeastoriginrecognitioncomplex AT remorohs humanizingtheyeastoriginrecognitioncomplex AT yuanliangzhai humanizingtheyeastoriginrecognitioncomplex AT dannyleung humanizingtheyeastoriginrecognitioncomplex AT bikkwoontye humanizingtheyeastoriginrecognitioncomplex
_version_	1718388359088308224

Humanizing the yeast origin recognition complex

Ejemplares similares