Gene editing and elimination of latent herpes simplex virus in vivo

Herpes simplex virus establishes lifelong latency in ganglionic neurons, which are the source for recurrent infection. Here Aubert et al. report a promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases, which leads to a significant reduction in ganglion...

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Autores principales:	Martine Aubert, Daniel E. Strongin, Pavitra Roychoudhury, Michelle A. Loprieno, Anoria K. Haick, Lindsay M. Klouser, Laurence Stensland, Meei-Li Huang, Negar Makhsous, Alexander Tait, Harshana S. De Silva Feelixge, Roman Galetto, Philippe Duchateau, Alexander L. Greninger, Daniel Stone, Keith R. Jerome
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4d037a80a34400ba2411e4046361719
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spelling	oai:doaj.org-article:f4d037a80a34400ba2411e40463617192021-12-02T18:01:15ZGene editing and elimination of latent herpes simplex virus in vivo10.1038/s41467-020-17936-52041-1723https://doaj.org/article/f4d037a80a34400ba2411e40463617192020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17936-5https://doaj.org/toc/2041-1723Herpes simplex virus establishes lifelong latency in ganglionic neurons, which are the source for recurrent infection. Here Aubert et al. report a promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases, which leads to a significant reduction in ganglionic HSV loads and HSV reactivation.Martine AubertDaniel E. StronginPavitra RoychoudhuryMichelle A. LoprienoAnoria K. HaickLindsay M. KlouserLaurence StenslandMeei-Li HuangNegar MakhsousAlexander TaitHarshana S. De Silva FeelixgeRoman GalettoPhilippe DuchateauAlexander L. GreningerDaniel StoneKeith R. JeromeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martine Aubert Daniel E. Strongin Pavitra Roychoudhury Michelle A. Loprieno Anoria K. Haick Lindsay M. Klouser Laurence Stensland Meei-Li Huang Negar Makhsous Alexander Tait Harshana S. De Silva Feelixge Roman Galetto Philippe Duchateau Alexander L. Greninger Daniel Stone Keith R. Jerome Gene editing and elimination of latent herpes simplex virus in vivo
description	Herpes simplex virus establishes lifelong latency in ganglionic neurons, which are the source for recurrent infection. Here Aubert et al. report a promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases, which leads to a significant reduction in ganglionic HSV loads and HSV reactivation.
format	article
author	Martine Aubert Daniel E. Strongin Pavitra Roychoudhury Michelle A. Loprieno Anoria K. Haick Lindsay M. Klouser Laurence Stensland Meei-Li Huang Negar Makhsous Alexander Tait Harshana S. De Silva Feelixge Roman Galetto Philippe Duchateau Alexander L. Greninger Daniel Stone Keith R. Jerome
author_facet	Martine Aubert Daniel E. Strongin Pavitra Roychoudhury Michelle A. Loprieno Anoria K. Haick Lindsay M. Klouser Laurence Stensland Meei-Li Huang Negar Makhsous Alexander Tait Harshana S. De Silva Feelixge Roman Galetto Philippe Duchateau Alexander L. Greninger Daniel Stone Keith R. Jerome
author_sort	Martine Aubert
title	Gene editing and elimination of latent herpes simplex virus in vivo
title_short	Gene editing and elimination of latent herpes simplex virus in vivo
title_full	Gene editing and elimination of latent herpes simplex virus in vivo
title_fullStr	Gene editing and elimination of latent herpes simplex virus in vivo
title_full_unstemmed	Gene editing and elimination of latent herpes simplex virus in vivo
title_sort	gene editing and elimination of latent herpes simplex virus in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4d037a80a34400ba2411e4046361719
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Gene editing and elimination of latent herpes simplex virus in vivo

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