Gene editing and elimination of latent herpes simplex virus in vivo

Gene editing and elimination of latent herpes simplex virus in vivo

Herpes simplex virus establishes lifelong latency in ganglionic neurons, which are the source for recurrent infection. Here Aubert et al. report a promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases, which leads to a significant reduction in ganglion...

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Main Authors: Martine Aubert, Daniel E. Strongin, Pavitra Roychoudhury, Michelle A. Loprieno, Anoria K. Haick, Lindsay M. Klouser, Laurence Stensland, Meei-Li Huang, Negar Makhsous, Alexander Tait, Harshana S. De Silva Feelixge, Roman Galetto, Philippe Duchateau, Alexander L. Greninger, Daniel Stone, Keith R. Jerome
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/f4d037a80a34400ba2411e4046361719
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https://doaj.org/article/f4d037a80a34400ba2411e4046361719

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