Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization
Abstract Distinct mutations in the secreted extracellular matrix protein, fibulin-3 (F3), have been associated with a number of ocular diseases ranging from primary open angle glaucoma to cuticular age-related macular degeneration to a rare macular dystrophy, Malattia Leventinese (ML). The R345W F3...
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Autores principales: | DaNae R. Woodard, Emi Nakahara, John D. Hulleman |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/f4d1cbf2ae3f44988272f1e62004c969 |
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