Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design

The cancer cases are increasing in fast pace; most of them are resulted from exposure to harmful pollutants. Genetic factors are responsible for cancer only to a small extent. Prevention and cure of cancer should be considered as a high priority because of severity of cancer-related issues. Some can...

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Autor principal:	Atukuri Dorababu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Anticancer activity Coumarin-heterocycle hybrids Drug-design Structure-activity relationship Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/f4d1ed8b78b34b4ba6c94803a3c05229
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spelling	oai:doaj.org-article:f4d1ed8b78b34b4ba6c94803a3c052292021-12-03T04:01:36ZCoumarin-heterocycle framework: A privileged approach in promising anticancer drug design2772-417410.1016/j.ejmcr.2021.100006https://doaj.org/article/f4d1ed8b78b34b4ba6c94803a3c052292021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2772417421000066https://doaj.org/toc/2772-4174The cancer cases are increasing in fast pace; most of them are resulted from exposure to harmful pollutants. Genetic factors are responsible for cancer only to a small extent. Prevention and cure of cancer should be considered as a high priority because of severity of cancer-related issues. Some cancer types caused by microbes may be prevented by vaccines. However, possibility of vaccine-development for other cancer types is very scarce. Hence, chemotherapeutic regimens have been developed for treatment of cancer. There are very serious side effects and drug-resistance arising from chemotherapy. So, the research to be undertaken is drug-discovery for cancer treatment associated with least side effects. The research literature infers that coumarin derivatives are promising pharmacological agents. Particularly, coumarin analogs are shown to be potent antitumor agents with low cytotoxicity. Also, coumarin-heterocycle hybrid approach has been resulted in efficient anticancer agents. Hence, anticancer activity of coumarin-heterocycle derivatives reported recently is compiled and evaluated critically. The review is organized based on type of heterocycle appended to coumarin moiety. Also, with structure-activity relationship, antitumor activity of various coumarin analogs has been discussed. This work would aid researchers in identifying promising antitumor molecules.Atukuri DorababuElsevierarticleAnticancer activityCoumarin-heterocycle hybridsDrug-designStructure-activity relationshipPharmacy and materia medicaRS1-441Other systems of medicineRZ201-999ENEuropean Journal of Medicinal Chemistry Reports, Vol 2, Iss , Pp 100006- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anticancer activity Coumarin-heterocycle hybrids Drug-design Structure-activity relationship Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
spellingShingle	Anticancer activity Coumarin-heterocycle hybrids Drug-design Structure-activity relationship Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999 Atukuri Dorababu Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
description	The cancer cases are increasing in fast pace; most of them are resulted from exposure to harmful pollutants. Genetic factors are responsible for cancer only to a small extent. Prevention and cure of cancer should be considered as a high priority because of severity of cancer-related issues. Some cancer types caused by microbes may be prevented by vaccines. However, possibility of vaccine-development for other cancer types is very scarce. Hence, chemotherapeutic regimens have been developed for treatment of cancer. There are very serious side effects and drug-resistance arising from chemotherapy. So, the research to be undertaken is drug-discovery for cancer treatment associated with least side effects. The research literature infers that coumarin derivatives are promising pharmacological agents. Particularly, coumarin analogs are shown to be potent antitumor agents with low cytotoxicity. Also, coumarin-heterocycle hybrid approach has been resulted in efficient anticancer agents. Hence, anticancer activity of coumarin-heterocycle derivatives reported recently is compiled and evaluated critically. The review is organized based on type of heterocycle appended to coumarin moiety. Also, with structure-activity relationship, antitumor activity of various coumarin analogs has been discussed. This work would aid researchers in identifying promising antitumor molecules.
format	article
author	Atukuri Dorababu
author_facet	Atukuri Dorababu
author_sort	Atukuri Dorababu
title	Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
title_short	Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
title_full	Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
title_fullStr	Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
title_full_unstemmed	Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
title_sort	coumarin-heterocycle framework: a privileged approach in promising anticancer drug design
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f4d1ed8b78b34b4ba6c94803a3c05229
work_keys_str_mv	AT atukuridorababu coumarinheterocycleframeworkaprivilegedapproachinpromisinganticancerdrugdesign
_version_	1718373965965033472

Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design

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