Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines

Background Colon carcinoma growth depends on many factors such as, different organisms, and immune cells, which induce and produce inflammatory cytokines. Umbelliprenin is a naturally prenylated coumarin with anti-inflammatory activities. Its ability to induce cancer cell death has shown variation...

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Autores principales:	Maryam Hamidinia, Mohammad Ramezani, Zahra Mojtahedi
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2013
Materias:	apoptosis colorectal neoplasms umbelliprenin Medicine R
Acceso en línea:	https://doaj.org/article/f4d505627c484ac0a02fdb7ee520ca75
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spelling	oai:doaj.org-article:f4d505627c484ac0a02fdb7ee520ca752021-11-14T07:53:43ZCytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines2783-243010.17795/acr-12476https://doaj.org/article/f4d505627c484ac0a02fdb7ee520ca752013-12-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45455_38f02efb09f179d2e79fd6c8b2099f66.pdfhttps://doaj.org/toc/2783-2430Background Colon carcinoma growth depends on many factors such as, different organisms, and immune cells, which induce and produce inflammatory cytokines. Umbelliprenin is a naturally prenylated coumarin with anti-inflammatory activities. Its ability to induce cancer cell death has shown variation on different cancer cell lines. Objectives 7-Prenyloxycoumarins, including umbelliprenin have been widely investigated because of their pharmacological activities. This paper shows the effect of umbelliprenin on colon cancer cell lines. Material and Methods In the present study, invasive SW48 and noninvasive SW1116 were treated with umbelliprenin (6.25, 12.5, 25, 50, 100, and 200 μM), and the cytotoxicity was determined using a methyl thiazolelydiphenyl-tetrazolium bromide (MTT) assay. Results Umbelliprenin had significant cytotoxic activity against SW48 cells at all study concentrations (except for 6.25 μM), with IC50 values of 117, 77, and 69 μM after 24, 48, and 72 h, respectively. However, it was cytotoxic against SW1116 only at higher concentrations of 100 and 200 μM (34% and 64% cell death). At lower concentrations, umbelliprenin showed a significant proliferative effect on this noninvasive cancer cell line. Our data were validated by eye and microscopic images. Conclusions We found a moderate cytotoxic activity of umbelliprenin against invasive SW48 cells, and both cytotoxic and proliferative effects on noninvasive SW1116 cells. Therefore, using umbelliprenin as an anti-inflammatory or cytotoxic compound for patients with colon cancer should be used with care.Maryam HamidiniaMohammad RamezaniZahra MojtahediShiraz University of Medical Sciencesarticleapoptosiscolorectal neoplasmsumbellipreninMedicineRENIranian Journal of Colorectal Research, Vol 1, Iss 3, Pp 1-1 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis colorectal neoplasms umbelliprenin Medicine R
spellingShingle	apoptosis colorectal neoplasms umbelliprenin Medicine R Maryam Hamidinia Mohammad Ramezani Zahra Mojtahedi Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
description	Background Colon carcinoma growth depends on many factors such as, different organisms, and immune cells, which induce and produce inflammatory cytokines. Umbelliprenin is a naturally prenylated coumarin with anti-inflammatory activities. Its ability to induce cancer cell death has shown variation on different cancer cell lines. Objectives 7-Prenyloxycoumarins, including umbelliprenin have been widely investigated because of their pharmacological activities. This paper shows the effect of umbelliprenin on colon cancer cell lines. Material and Methods In the present study, invasive SW48 and noninvasive SW1116 were treated with umbelliprenin (6.25, 12.5, 25, 50, 100, and 200 μM), and the cytotoxicity was determined using a methyl thiazolelydiphenyl-tetrazolium bromide (MTT) assay. Results Umbelliprenin had significant cytotoxic activity against SW48 cells at all study concentrations (except for 6.25 μM), with IC50 values of 117, 77, and 69 μM after 24, 48, and 72 h, respectively. However, it was cytotoxic against SW1116 only at higher concentrations of 100 and 200 μM (34% and 64% cell death). At lower concentrations, umbelliprenin showed a significant proliferative effect on this noninvasive cancer cell line. Our data were validated by eye and microscopic images. Conclusions We found a moderate cytotoxic activity of umbelliprenin against invasive SW48 cells, and both cytotoxic and proliferative effects on noninvasive SW1116 cells. Therefore, using umbelliprenin as an anti-inflammatory or cytotoxic compound for patients with colon cancer should be used with care.
format	article
author	Maryam Hamidinia Mohammad Ramezani Zahra Mojtahedi
author_facet	Maryam Hamidinia Mohammad Ramezani Zahra Mojtahedi
author_sort	Maryam Hamidinia
title	Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
title_short	Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
title_full	Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
title_fullStr	Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
title_full_unstemmed	Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines
title_sort	cytotoxic/proliferative effects of umbelliprenin on colon cancer cell lines
publisher	Shiraz University of Medical Sciences
publishDate	2013
url	https://doaj.org/article/f4d505627c484ac0a02fdb7ee520ca75
work_keys_str_mv	AT maryamhamidinia cytotoxicproliferativeeffectsofumbellipreninoncoloncancercelllines AT mohammadramezani cytotoxicproliferativeeffectsofumbellipreninoncoloncancercelllines AT zahramojtahedi cytotoxicproliferativeeffectsofumbellipreninoncoloncancercelllines
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Cytotoxic/Proliferative Effects of Umbelliprenin on Colon Cancer Cell Lines

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