Periplocin and cardiac glycosides suppress the unfolded protein response

Periplocin and cardiac glycosides suppress the unfolded protein response

Abstract The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases. Therefore, the compounds modulating UPR may provide molecular insights...

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Main Authors: Muneshige Tokugawa, Yasumichi Inoue, Kan’ichiro Ishiuchi, Chisane Kujirai, Michiyo Matsuno, Masaki Ri, Yuka Itoh, Chiharu Miyajima, Daisuke Morishita, Nobumichi Ohoka, Shinsuke Iida, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f4d5583a2ef44886af048e669358049f
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https://doaj.org/article/f4d5583a2ef44886af048e669358049f

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