Computer modeling describes gravity-related adaptation in cell cultures.

Questions about the changes of biological systems in response to hostile environmental factors are important but not easy to answer. Often, the traditional description with differential equations is difficult due to the overwhelming complexity of the living systems. Another way to describe complex s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ludmil B Alexandrov, Stoyana Alexandrova, Anny Usheva
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4dbf2b6c9bd421dafd4c3d1c94e26b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4dbf2b6c9bd421dafd4c3d1c94e26b5
record_format	dspace
spelling	oai:doaj.org-article:f4dbf2b6c9bd421dafd4c3d1c94e26b52021-11-25T06:27:21ZComputer modeling describes gravity-related adaptation in cell cultures.1932-620310.1371/journal.pone.0008332https://doaj.org/article/f4dbf2b6c9bd421dafd4c3d1c94e26b52009-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20016778/?tool=EBIhttps://doaj.org/toc/1932-6203Questions about the changes of biological systems in response to hostile environmental factors are important but not easy to answer. Often, the traditional description with differential equations is difficult due to the overwhelming complexity of the living systems. Another way to describe complex systems is by simulating them with phenomenological models such as the well-known evolutionary agent-based model (EABM). Here we developed an EABM to simulate cell colonies as a multi-agent system that adapts to hyper-gravity in starvation conditions. In the model, the cell's heritable characteristics are generated and transferred randomly to offspring cells. After a qualitative validation of the model at normal gravity, we simulate cellular growth in hyper-gravity conditions. The obtained data are consistent with previously confirmed theoretical and experimental findings for bacterial behavior in environmental changes, including the experimental data from the microgravity Atlantis and the Hypergravity 3000 experiments. Our results demonstrate that it is possible to utilize an EABM with realistic qualitative description to examine the effects of hypergravity and starvation on complex cellular entities.Ludmil B AlexandrovStoyana AlexandrovaAnny UshevaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 12, p e8332 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ludmil B Alexandrov Stoyana Alexandrova Anny Usheva Computer modeling describes gravity-related adaptation in cell cultures.
description	Questions about the changes of biological systems in response to hostile environmental factors are important but not easy to answer. Often, the traditional description with differential equations is difficult due to the overwhelming complexity of the living systems. Another way to describe complex systems is by simulating them with phenomenological models such as the well-known evolutionary agent-based model (EABM). Here we developed an EABM to simulate cell colonies as a multi-agent system that adapts to hyper-gravity in starvation conditions. In the model, the cell's heritable characteristics are generated and transferred randomly to offspring cells. After a qualitative validation of the model at normal gravity, we simulate cellular growth in hyper-gravity conditions. The obtained data are consistent with previously confirmed theoretical and experimental findings for bacterial behavior in environmental changes, including the experimental data from the microgravity Atlantis and the Hypergravity 3000 experiments. Our results demonstrate that it is possible to utilize an EABM with realistic qualitative description to examine the effects of hypergravity and starvation on complex cellular entities.
format	article
author	Ludmil B Alexandrov Stoyana Alexandrova Anny Usheva
author_facet	Ludmil B Alexandrov Stoyana Alexandrova Anny Usheva
author_sort	Ludmil B Alexandrov
title	Computer modeling describes gravity-related adaptation in cell cultures.
title_short	Computer modeling describes gravity-related adaptation in cell cultures.
title_full	Computer modeling describes gravity-related adaptation in cell cultures.
title_fullStr	Computer modeling describes gravity-related adaptation in cell cultures.
title_full_unstemmed	Computer modeling describes gravity-related adaptation in cell cultures.
title_sort	computer modeling describes gravity-related adaptation in cell cultures.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f4dbf2b6c9bd421dafd4c3d1c94e26b5
work_keys_str_mv	AT ludmilbalexandrov computermodelingdescribesgravityrelatedadaptationincellcultures AT stoyanaalexandrova computermodelingdescribesgravityrelatedadaptationincellcultures AT annyusheva computermodelingdescribesgravityrelatedadaptationincellcultures
_version_	1718413717450784768

Computer modeling describes gravity-related adaptation in cell cultures.

Ejemplares similares