Immunotropic effects of mesotherapy used for correction of age-related skin changes

Rapid progression of aesthetic medicine is a distinctive feature of present decade. In this area, leading position is taken by injection cosmetology, which is associated with an opportunity of pathogenetic approach to resolution of cosmetic problems primarily caused by skin aging. The most commonly...

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Autores principales:	L. P. Sizyakina, I. I. Andrreeva, A. I. Sergeeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	mesotherapy innate immunity adaptive immunity regulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f4ddc9ab86d64d8d881c87f3d23f4b42
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spelling	oai:doaj.org-article:f4ddc9ab86d64d8d881c87f3d23f4b422021-11-18T08:03:51ZImmunotropic effects of mesotherapy used for correction of age-related skin changes1563-06252313-741X10.15789/1563-0625-IEO-2205https://doaj.org/article/f4ddc9ab86d64d8d881c87f3d23f4b422021-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2205https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XRapid progression of aesthetic medicine is a distinctive feature of present decade. In this area, leading position is taken by injection cosmetology, which is associated with an opportunity of pathogenetic approach to resolution of cosmetic problems primarily caused by skin aging. The most commonly used mesotherapy drugs, along with hyaluronic acid, are vitamins, amino acids, and microelements. Skin aging is associated with quantitative and functional changes in the local immune cell populations. In this case, it is rational to assume distinct effects of peptide complexes upon functional potential of immunocompetent cells. The aim of this study was to analyze time-dependent changes of some immune parameters after mesotherapy with a complex of hyaluronic acid and peptides. The observation group consisted of 26 women who received their course of mesotherapy for the first time. Objective instrumental evaluation of the effect with Aramo Smart Lite device showed that, after mesotherapy, the skin quality was significantly improving in comparison with pre-treatment conditions, due to decreased relief of skin creases and wrinkles, with a tendency for reduction of this effect six months later. When comparing the results of immunological testing in the patients after the course of treatment with the data before starting the therapy, we have found redistribution in the lymphoid cell populations, i.e., increased proportion of T-lymphocytes, decreased amounts of B cells, and CD16+ natural killers. Declined numbers of T-lymphocytes expressing early activation marker were associated with increased proportion of peripheral Treg lymphocytes. We have also detected activation of antibody production which manifested as increased levels of all major classes of serum immunoglobulins. Enhanced spontaneous oxidative activity of neutrophils was also noted. The results of immunological monitoring showed that, three months post-treatment, none of the quantitative and functional parameters of immunity was changed, as compared with the results obtained immediately after ending the mesotherapy. Six months later, however, all these indexes returned to their initial positions assessed before the cosmetic procedure. The changes in systemic immune response following mesotherapy with peptide complexes affect the mechanisms of both innate and acquired immunity, including differentiation of lymphocytes, their regulatory functions and activation potential, and provide modulation of effector reactions. Complete restoration of initial immune parameters is observed within six months.L. P. SizyakinaI. I. AndrreevaA. I. SergeevaSPb RAACIarticlemesotherapyinnate immunityadaptive immunityregulationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 3, Pp 585-592 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	mesotherapy innate immunity adaptive immunity regulation Immunologic diseases. Allergy RC581-607
spellingShingle	mesotherapy innate immunity adaptive immunity regulation Immunologic diseases. Allergy RC581-607 L. P. Sizyakina I. I. Andrreeva A. I. Sergeeva Immunotropic effects of mesotherapy used for correction of age-related skin changes
description	Rapid progression of aesthetic medicine is a distinctive feature of present decade. In this area, leading position is taken by injection cosmetology, which is associated with an opportunity of pathogenetic approach to resolution of cosmetic problems primarily caused by skin aging. The most commonly used mesotherapy drugs, along with hyaluronic acid, are vitamins, amino acids, and microelements. Skin aging is associated with quantitative and functional changes in the local immune cell populations. In this case, it is rational to assume distinct effects of peptide complexes upon functional potential of immunocompetent cells. The aim of this study was to analyze time-dependent changes of some immune parameters after mesotherapy with a complex of hyaluronic acid and peptides. The observation group consisted of 26 women who received their course of mesotherapy for the first time. Objective instrumental evaluation of the effect with Aramo Smart Lite device showed that, after mesotherapy, the skin quality was significantly improving in comparison with pre-treatment conditions, due to decreased relief of skin creases and wrinkles, with a tendency for reduction of this effect six months later. When comparing the results of immunological testing in the patients after the course of treatment with the data before starting the therapy, we have found redistribution in the lymphoid cell populations, i.e., increased proportion of T-lymphocytes, decreased amounts of B cells, and CD16+ natural killers. Declined numbers of T-lymphocytes expressing early activation marker were associated with increased proportion of peripheral Treg lymphocytes. We have also detected activation of antibody production which manifested as increased levels of all major classes of serum immunoglobulins. Enhanced spontaneous oxidative activity of neutrophils was also noted. The results of immunological monitoring showed that, three months post-treatment, none of the quantitative and functional parameters of immunity was changed, as compared with the results obtained immediately after ending the mesotherapy. Six months later, however, all these indexes returned to their initial positions assessed before the cosmetic procedure. The changes in systemic immune response following mesotherapy with peptide complexes affect the mechanisms of both innate and acquired immunity, including differentiation of lymphocytes, their regulatory functions and activation potential, and provide modulation of effector reactions. Complete restoration of initial immune parameters is observed within six months.
format	article
author	L. P. Sizyakina I. I. Andrreeva A. I. Sergeeva
author_facet	L. P. Sizyakina I. I. Andrreeva A. I. Sergeeva
author_sort	L. P. Sizyakina
title	Immunotropic effects of mesotherapy used for correction of age-related skin changes
title_short	Immunotropic effects of mesotherapy used for correction of age-related skin changes
title_full	Immunotropic effects of mesotherapy used for correction of age-related skin changes
title_fullStr	Immunotropic effects of mesotherapy used for correction of age-related skin changes
title_full_unstemmed	Immunotropic effects of mesotherapy used for correction of age-related skin changes
title_sort	immunotropic effects of mesotherapy used for correction of age-related skin changes
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/f4ddc9ab86d64d8d881c87f3d23f4b42
work_keys_str_mv	AT lpsizyakina immunotropiceffectsofmesotherapyusedforcorrectionofagerelatedskinchanges AT iiandrreeva immunotropiceffectsofmesotherapyusedforcorrectionofagerelatedskinchanges AT aisergeeva immunotropiceffectsofmesotherapyusedforcorrectionofagerelatedskinchanges
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Immunotropic effects of mesotherapy used for correction of age-related skin changes

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