Effects of Berberine on Atherosclerosis

Atherosclerosis is an epidemic across the globe[A1], and its morbidity and mortality remain high, involving various complications and poor prognoses. In atherosclerosis, endothelial cells (ECs) dysfunction, vascular smooth muscle cells (VSMCs) migration and proliferation, foam cell formation, and in...

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Autores principales:	Rui Rui, Haolan Yang, Yanke Liu, Yue Zhou, Xudong Xu, Chaohong Li, Shuying Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	berberine atherosclerosis endothelial cell vascular smooth muscle cell inflammatory cell vascular stem cell Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f4e1d21ec7e8433398757d55d2160357
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spelling	oai:doaj.org-article:f4e1d21ec7e8433398757d55d21603572021-12-01T06:03:47ZEffects of Berberine on Atherosclerosis1663-981210.3389/fphar.2021.764175https://doaj.org/article/f4e1d21ec7e8433398757d55d21603572021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.764175/fullhttps://doaj.org/toc/1663-9812Atherosclerosis is an epidemic across the globe[A1], and its morbidity and mortality remain high, involving various complications and poor prognoses. In atherosclerosis, endothelial cells (ECs) dysfunction, vascular smooth muscle cells (VSMCs) migration and proliferation, foam cell formation, and inflammatory cell recruitment contribute to disease progression. Vascular stem cells (VSCs) also play a critical role in the cardiovascular system. Important data showed that the simultaneous increase of proliferation and apoptosis of VSMCs is the main cause of graft vein stenosis, suggesting that inhibition of VSMCs proliferation and apoptosis simultaneously is an important strategy for the treatment of atherosclerotic stenosis. Complementary and alternative medicine use among patients with cardiovascular disease (CVD) is growing. Berberine is an extract of Chinese traditional herbs that is known for its antimicrobial and anti-inflammatory effects in the digestive system. Its underlying anti-CVD mechanisms are currently attracting interest, and its pharmacological actions, such as antioxidation, regulation of neurotransmitters and enzymes, and cholesterol-lowering effects, have been substantiated. Recent studying found that berberine could inhibit both the proliferation and apoptosis of VSMCs induced by mechanical stretch stress simultaneously, which suggests that berberine might be an excellent drug to treat atherosclerosis. This review will focus on the recent progress of the effect of berberine on vascular cells, especially VSMCs, to provide important data and a new perspective for the application of berberine in anti-atherosclerosis.Rui RuiHaolan YangYanke LiuYue ZhouXudong XuChaohong LiShuying LiuFrontiers Media S.A.articleberberineatherosclerosisendothelial cellvascular smooth muscle cellinflammatory cellvascular stem cellTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	berberine atherosclerosis endothelial cell vascular smooth muscle cell inflammatory cell vascular stem cell Therapeutics. Pharmacology RM1-950
spellingShingle	berberine atherosclerosis endothelial cell vascular smooth muscle cell inflammatory cell vascular stem cell Therapeutics. Pharmacology RM1-950 Rui Rui Haolan Yang Yanke Liu Yue Zhou Xudong Xu Chaohong Li Shuying Liu Effects of Berberine on Atherosclerosis
description	Atherosclerosis is an epidemic across the globe[A1], and its morbidity and mortality remain high, involving various complications and poor prognoses. In atherosclerosis, endothelial cells (ECs) dysfunction, vascular smooth muscle cells (VSMCs) migration and proliferation, foam cell formation, and inflammatory cell recruitment contribute to disease progression. Vascular stem cells (VSCs) also play a critical role in the cardiovascular system. Important data showed that the simultaneous increase of proliferation and apoptosis of VSMCs is the main cause of graft vein stenosis, suggesting that inhibition of VSMCs proliferation and apoptosis simultaneously is an important strategy for the treatment of atherosclerotic stenosis. Complementary and alternative medicine use among patients with cardiovascular disease (CVD) is growing. Berberine is an extract of Chinese traditional herbs that is known for its antimicrobial and anti-inflammatory effects in the digestive system. Its underlying anti-CVD mechanisms are currently attracting interest, and its pharmacological actions, such as antioxidation, regulation of neurotransmitters and enzymes, and cholesterol-lowering effects, have been substantiated. Recent studying found that berberine could inhibit both the proliferation and apoptosis of VSMCs induced by mechanical stretch stress simultaneously, which suggests that berberine might be an excellent drug to treat atherosclerosis. This review will focus on the recent progress of the effect of berberine on vascular cells, especially VSMCs, to provide important data and a new perspective for the application of berberine in anti-atherosclerosis.
format	article
author	Rui Rui Haolan Yang Yanke Liu Yue Zhou Xudong Xu Chaohong Li Shuying Liu
author_facet	Rui Rui Haolan Yang Yanke Liu Yue Zhou Xudong Xu Chaohong Li Shuying Liu
author_sort	Rui Rui
title	Effects of Berberine on Atherosclerosis
title_short	Effects of Berberine on Atherosclerosis
title_full	Effects of Berberine on Atherosclerosis
title_fullStr	Effects of Berberine on Atherosclerosis
title_full_unstemmed	Effects of Berberine on Atherosclerosis
title_sort	effects of berberine on atherosclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f4e1d21ec7e8433398757d55d2160357
work_keys_str_mv	AT ruirui effectsofberberineonatherosclerosis AT haolanyang effectsofberberineonatherosclerosis AT yankeliu effectsofberberineonatherosclerosis AT yuezhou effectsofberberineonatherosclerosis AT xudongxu effectsofberberineonatherosclerosis AT chaohongli effectsofberberineonatherosclerosis AT shuyingliu effectsofberberineonatherosclerosis
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Effects of Berberine on Atherosclerosis

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