Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modification...

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Autores principales:	Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4e944a381d141e282c85ec2a114b48e
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spelling	oai:doaj.org-article:f4e944a381d141e282c85ec2a114b48e2021-12-02T15:38:38ZPhosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain10.1038/ncomms152332041-1723https://doaj.org/article/f4e944a381d141e282c85ec2a114b48e2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15233https://doaj.org/toc/2041-1723The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modifications by regulatory enzymes.Eric B. GibbsFeiyue LuBede PortzMichael J. FisherBrenda P. MedellinTatiana N. LaremoreYan Jessie ZhangDavid S. GilmourScott A. ShowalterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric B. Gibbs Feiyue Lu Bede Portz Michael J. Fisher Brenda P. Medellin Tatiana N. Laremore Yan Jessie Zhang David S. Gilmour Scott A. Showalter Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
description	The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modifications by regulatory enzymes.
format	article
author	Eric B. Gibbs Feiyue Lu Bede Portz Michael J. Fisher Brenda P. Medellin Tatiana N. Laremore Yan Jessie Zhang David S. Gilmour Scott A. Showalter
author_facet	Eric B. Gibbs Feiyue Lu Bede Portz Michael J. Fisher Brenda P. Medellin Tatiana N. Laremore Yan Jessie Zhang David S. Gilmour Scott A. Showalter
author_sort	Eric B. Gibbs
title	Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
title_short	Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
title_full	Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
title_fullStr	Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
title_full_unstemmed	Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
title_sort	phosphorylation induces sequence-specific conformational switches in the rna polymerase ii c-terminal domain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f4e944a381d141e282c85ec2a114b48e
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Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

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