Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modification...

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Autores principales: Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/f4e944a381d141e282c85ec2a114b48e
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