Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcripti...

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Autores principales:	Xiangjia Zhu, Yu Du, Dan Li, Jie Xu, Qingfeng Wu, Wenwen He, Keke Zhang, Jie Zhu, Linying Guo, Ming Qi, Ailin Liu, Jiao Qi, Guangyu Wang, Jiaqi Meng, Zhenglin Yang, Kang Zhang, Yi Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4e9554313524c7c96cb9661fa29189d
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spelling	oai:doaj.org-article:f4e9554313524c7c96cb9661fa29189d2021-12-02T18:15:27ZAberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia10.1038/s41467-021-22041-22041-1723https://doaj.org/article/f4e9554313524c7c96cb9661fa29189d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22041-2https://doaj.org/toc/2041-1723High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcription factor MAF and TGF-β1 signaling.Xiangjia ZhuYu DuDan LiJie XuQingfeng WuWenwen HeKeke ZhangJie ZhuLinying GuoMing QiAilin LiuJiao QiGuangyu WangJiaqi MengZhenglin YangKang ZhangYi LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangjia Zhu Yu Du Dan Li Jie Xu Qingfeng Wu Wenwen He Keke Zhang Jie Zhu Linying Guo Ming Qi Ailin Liu Jiao Qi Guangyu Wang Jiaqi Meng Zhenglin Yang Kang Zhang Yi Lu Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
description	High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcription factor MAF and TGF-β1 signaling.
format	article
author	Xiangjia Zhu Yu Du Dan Li Jie Xu Qingfeng Wu Wenwen He Keke Zhang Jie Zhu Linying Guo Ming Qi Ailin Liu Jiao Qi Guangyu Wang Jiaqi Meng Zhenglin Yang Kang Zhang Yi Lu
author_facet	Xiangjia Zhu Yu Du Dan Li Jie Xu Qingfeng Wu Wenwen He Keke Zhang Jie Zhu Linying Guo Ming Qi Ailin Liu Jiao Qi Guangyu Wang Jiaqi Meng Zhenglin Yang Kang Zhang Yi Lu
author_sort	Xiangjia Zhu
title	Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
title_short	Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
title_full	Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
title_fullStr	Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
title_full_unstemmed	Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
title_sort	aberrant tgf-β1 signaling activation by maf underlies pathological lens growth in high myopia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4e9554313524c7c96cb9661fa29189d
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Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

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