Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcripti...

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Autores principales: Xiangjia Zhu, Yu Du, Dan Li, Jie Xu, Qingfeng Wu, Wenwen He, Keke Zhang, Jie Zhu, Linying Guo, Ming Qi, Ailin Liu, Jiao Qi, Guangyu Wang, Jiaqi Meng, Zhenglin Yang, Kang Zhang, Yi Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/f4e9554313524c7c96cb9661fa29189d
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