Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review

Therapeutic plasma exchange (TPE) is an adjunctive intervention to immunosuppression for the treatment of severe renal involvement or lung hemorrhage in patients with ANCA-associated vasculitis (AAV). Patients with AAV have an increased risk for progression to end-stage kidney disease (ESKD) or deat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stathis Tsiakas, Smaragdi Marinaki, Sophia Lionaki, John Boletis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	plasma exchange plasmapheresis ANCA-associated vasculitis kidney disease review Medicine R
Acceso en línea:	https://doaj.org/article/f4ec00aa876844899a30133c5b7980f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4ec00aa876844899a30133c5b7980f0
record_format	dspace
spelling	oai:doaj.org-article:f4ec00aa876844899a30133c5b7980f02021-11-11T17:46:24ZPlasma Exchange in ANCA-Associated Vasculitis: A Narrative Review10.3390/jcm102151542077-0383https://doaj.org/article/f4ec00aa876844899a30133c5b7980f02021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5154https://doaj.org/toc/2077-0383Therapeutic plasma exchange (TPE) is an adjunctive intervention to immunosuppression for the treatment of severe renal involvement or lung hemorrhage in patients with ANCA-associated vasculitis (AAV). Patients with AAV have an increased risk for progression to end-stage kidney disease (ESKD) or death despite advances in immunosuppressive therapy. The potential pathogenicity of ANCA makes TPE a reasonable treatment approach for the life-threatening complications of AAV. The efficacy of intensive TPE in rapidly progressive glomerulonephritis was originally described in small studies almost four decades ago. Further randomized trials examined the addition of TPE to standard of care, exhibiting mixed results in both patient and renal survival. The largest clinical trial to date, PEXIVAS, failed to demonstrate a clear benefit for TPE in severe AAV. In light of new evidence, the role of TPE remains controversial across the vasculitis medical community. The purpose of this review is to summarize the clinical indications and the current available data for the use of TPE in patients with severe AAV.Stathis TsiakasSmaragdi MarinakiSophia LionakiJohn BoletisMDPI AGarticleplasma exchangeplasmapheresisANCA-associated vasculitiskidney diseasereviewMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5154, p 5154 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasma exchange plasmapheresis ANCA-associated vasculitis kidney disease review Medicine R
spellingShingle	plasma exchange plasmapheresis ANCA-associated vasculitis kidney disease review Medicine R Stathis Tsiakas Smaragdi Marinaki Sophia Lionaki John Boletis Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
description	Therapeutic plasma exchange (TPE) is an adjunctive intervention to immunosuppression for the treatment of severe renal involvement or lung hemorrhage in patients with ANCA-associated vasculitis (AAV). Patients with AAV have an increased risk for progression to end-stage kidney disease (ESKD) or death despite advances in immunosuppressive therapy. The potential pathogenicity of ANCA makes TPE a reasonable treatment approach for the life-threatening complications of AAV. The efficacy of intensive TPE in rapidly progressive glomerulonephritis was originally described in small studies almost four decades ago. Further randomized trials examined the addition of TPE to standard of care, exhibiting mixed results in both patient and renal survival. The largest clinical trial to date, PEXIVAS, failed to demonstrate a clear benefit for TPE in severe AAV. In light of new evidence, the role of TPE remains controversial across the vasculitis medical community. The purpose of this review is to summarize the clinical indications and the current available data for the use of TPE in patients with severe AAV.
format	article
author	Stathis Tsiakas Smaragdi Marinaki Sophia Lionaki John Boletis
author_facet	Stathis Tsiakas Smaragdi Marinaki Sophia Lionaki John Boletis
author_sort	Stathis Tsiakas
title	Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
title_short	Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
title_full	Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
title_fullStr	Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
title_full_unstemmed	Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review
title_sort	plasma exchange in anca-associated vasculitis: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f4ec00aa876844899a30133c5b7980f0
work_keys_str_mv	AT stathistsiakas plasmaexchangeinancaassociatedvasculitisanarrativereview AT smaragdimarinaki plasmaexchangeinancaassociatedvasculitisanarrativereview AT sophialionaki plasmaexchangeinancaassociatedvasculitisanarrativereview AT johnboletis plasmaexchangeinancaassociatedvasculitisanarrativereview
_version_	1718432036918657024

Plasma Exchange in ANCA-Associated Vasculitis: A Narrative Review

Ejemplares similares