Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury

Abstract Cardiovascular diseases such as myocardial infarction (MI) is a major contributor to human mortality and morbidity. The mammalian adult heart almost loses its plasticity to appreciably regenerate new cardiomyocytes after injuries, such as MI and heart failure. The neonatal heart exhibits ro...

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Autores principales:	Shuainan Li, Wenya Ma, Benzhi Cai
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Cardiomyocyte proliferation Heart regeneration Myocardial infarction Cardiovascular disease MicroRNAs Cardiac repair Medicine R
Acceso en línea:	https://doaj.org/article/f4f6a016ec0a47729c04bc850f12b1d0
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spelling	oai:doaj.org-article:f4f6a016ec0a47729c04bc850f12b1d02021-11-07T12:05:52ZTargeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury10.1186/s43556-021-00047-y2662-8651https://doaj.org/article/f4f6a016ec0a47729c04bc850f12b1d02021-11-01T00:00:00Zhttps://doi.org/10.1186/s43556-021-00047-yhttps://doaj.org/toc/2662-8651Abstract Cardiovascular diseases such as myocardial infarction (MI) is a major contributor to human mortality and morbidity. The mammalian adult heart almost loses its plasticity to appreciably regenerate new cardiomyocytes after injuries, such as MI and heart failure. The neonatal heart exhibits robust proliferative capacity when exposed to varying forms of myocardial damage. The ability of the neonatal heart to repair the injury and prevent pathological left ventricular remodeling leads to preserved or improved cardiac function. Therefore, promoting cardiomyocyte proliferation after injuries to reinitiate the process of cardiomyocyte regeneration, and suppress heart failure and other serious cardiovascular problems have become the primary goal of many researchers. Here, we review recent studies in this field and summarize the factors that act upon the proliferation of cardiomyocytes and cardiac repair after injury and discuss the new possibilities for potential clinical treatment strategies for cardiovascular diseases.Shuainan LiWenya MaBenzhi CaiSpringerarticleCardiomyocyte proliferationHeart regenerationMyocardial infarctionCardiovascular diseaseMicroRNAsCardiac repairMedicineRENMolecular Biomedicine, Vol 2, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiomyocyte proliferation Heart regeneration Myocardial infarction Cardiovascular disease MicroRNAs Cardiac repair Medicine R
spellingShingle	Cardiomyocyte proliferation Heart regeneration Myocardial infarction Cardiovascular disease MicroRNAs Cardiac repair Medicine R Shuainan Li Wenya Ma Benzhi Cai Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
description	Abstract Cardiovascular diseases such as myocardial infarction (MI) is a major contributor to human mortality and morbidity. The mammalian adult heart almost loses its plasticity to appreciably regenerate new cardiomyocytes after injuries, such as MI and heart failure. The neonatal heart exhibits robust proliferative capacity when exposed to varying forms of myocardial damage. The ability of the neonatal heart to repair the injury and prevent pathological left ventricular remodeling leads to preserved or improved cardiac function. Therefore, promoting cardiomyocyte proliferation after injuries to reinitiate the process of cardiomyocyte regeneration, and suppress heart failure and other serious cardiovascular problems have become the primary goal of many researchers. Here, we review recent studies in this field and summarize the factors that act upon the proliferation of cardiomyocytes and cardiac repair after injury and discuss the new possibilities for potential clinical treatment strategies for cardiovascular diseases.
format	article
author	Shuainan Li Wenya Ma Benzhi Cai
author_facet	Shuainan Li Wenya Ma Benzhi Cai
author_sort	Shuainan Li
title	Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
title_short	Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
title_full	Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
title_fullStr	Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
title_full_unstemmed	Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
title_sort	targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury
publisher	Springer
publishDate	2021
url	https://doaj.org/article/f4f6a016ec0a47729c04bc850f12b1d0
work_keys_str_mv	AT shuainanli targetingcardiomyocyteproliferationasakeyapproachofpromotingheartrepairafterinjury AT wenyama targetingcardiomyocyteproliferationasakeyapproachofpromotingheartrepairafterinjury AT benzhicai targetingcardiomyocyteproliferationasakeyapproachofpromotingheartrepairafterinjury
_version_	1718443585657896960

Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury

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