LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells

LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultu...

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Autores principales: Orapan Sripichai, Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Tiwaporn Nualkaew, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn
Formato: article
Lenguaje:EN
Publicado: PAGEPress Publications 2021
Materias:
thalassemia, erythroid, fetal hemoglobin, LSD1, RN-1
Diseases of the blood and blood-forming organs
RC633-647.5
Acceso en línea:https://doaj.org/article/f4f7685b6a5e43a99dd8c5878570edf6
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