LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells
Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultu...
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| Main Authors: | , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
PAGEPress Publications
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/f4f7685b6a5e43a99dd8c5878570edf6 |
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