Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer

This study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide w...

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Autores principales:	Lasmaryna Sirumapea, Mohammad Ali Zulfikar, Muhammad Bachri Amran, Anita Alni
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	meropenem molecularly imprinted polymer selective solid-phase extraction Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f4fafb6d419c42c0829fca1305f0fd8f
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spelling	oai:doaj.org-article:f4fafb6d419c42c0829fca1305f0fd8f2021-12-02T16:56:26ZSelective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer1411-94202460-157810.22146/ijc.64025https://doaj.org/article/f4fafb6d419c42c0829fca1305f0fd8f2021-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/64025https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578This study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide were applied as functional monomer, crosslinker agent, initiator, and solvent, respectively. Scanning electron microscopy, thermogravimetric analysis, Brunauer-Emmett-Teller analysis, and Fourier transform infrared spectroscopy were used to characterize the morphology, pore size, and structure of imprinted polymers. The maximum adsorption capacity was achieved at pH = 3, after 4 h contacted, under 150 rpm, and 25 mg of polymer applied. The maximum adsorption capacity of MeIP for meropenem was 51.963 mg/L; the synthesized polymer had superior selectivity to meropenem compared to that of the other antibiotics (imprinting factor, IF = 2.58). Furthermore, the thermodynamic and kinetic analyses indicated that the results were in accord with the Freundlich model and the pseudo-second-order kinetic model, respectively. MeIP was selective in batch adsorption, and molecularly imprinted solid-phase extraction protocols were selective to meropenem. It was then applied to analyze meropenem in human blood plasma and resulted in 78.52 ± 2.71 of recovery.Lasmaryna SirumapeaMohammad Ali ZulfikarMuhammad Bachri AmranAnita AlniDepartment of Chemistry, Universitas Gadjah Madaarticlemeropenemmolecularly imprinted polymerselectivesolid-phase extractionChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 5, Pp 1167-1179 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	meropenem molecularly imprinted polymer selective solid-phase extraction Chemistry QD1-999
spellingShingle	meropenem molecularly imprinted polymer selective solid-phase extraction Chemistry QD1-999 Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
description	This study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide were applied as functional monomer, crosslinker agent, initiator, and solvent, respectively. Scanning electron microscopy, thermogravimetric analysis, Brunauer-Emmett-Teller analysis, and Fourier transform infrared spectroscopy were used to characterize the morphology, pore size, and structure of imprinted polymers. The maximum adsorption capacity was achieved at pH = 3, after 4 h contacted, under 150 rpm, and 25 mg of polymer applied. The maximum adsorption capacity of MeIP for meropenem was 51.963 mg/L; the synthesized polymer had superior selectivity to meropenem compared to that of the other antibiotics (imprinting factor, IF = 2.58). Furthermore, the thermodynamic and kinetic analyses indicated that the results were in accord with the Freundlich model and the pseudo-second-order kinetic model, respectively. MeIP was selective in batch adsorption, and molecularly imprinted solid-phase extraction protocols were selective to meropenem. It was then applied to analyze meropenem in human blood plasma and resulted in 78.52 ± 2.71 of recovery.
format	article
author	Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni
author_facet	Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni
author_sort	Lasmaryna Sirumapea
title	Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
title_short	Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
title_full	Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
title_fullStr	Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
title_full_unstemmed	Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
title_sort	selective solid-phase extraction of meropenem from human blood plasma using a molecularly imprinted polymer
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/f4fafb6d419c42c0829fca1305f0fd8f
work_keys_str_mv	AT lasmarynasirumapea selectivesolidphaseextractionofmeropenemfromhumanbloodplasmausingamolecularlyimprintedpolymer AT mohammadalizulfikar selectivesolidphaseextractionofmeropenemfromhumanbloodplasmausingamolecularlyimprintedpolymer AT muhammadbachriamran selectivesolidphaseextractionofmeropenemfromhumanbloodplasmausingamolecularlyimprintedpolymer AT anitaalni selectivesolidphaseextractionofmeropenemfromhumanbloodplasmausingamolecularlyimprintedpolymer
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Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer

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