Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candid...

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Autores principales:	Sujit Pujhari, Jason L Rasgon
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	sars-cov-2 respiratory infectious diseases pluripotent stem cell animal model Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f4fb78db164c4e9dbed23e6a1ef87de1
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spelling	oai:doaj.org-article:f4fb78db164c4e9dbed23e6a1ef87de12021-11-17T14:21:58ZMice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness2150-55942150-560810.1080/21505594.2020.1763637https://doaj.org/article/f4fb78db164c4e9dbed23e6a1ef87de12020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1763637https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.Sujit PujhariJason L RasgonTaylor & Francis Grouparticlesars-cov-2respiratory infectious diseasespluripotent stem cellanimal modelInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 486-488 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 respiratory infectious diseases pluripotent stem cell animal model Infectious and parasitic diseases RC109-216
spellingShingle	sars-cov-2 respiratory infectious diseases pluripotent stem cell animal model Infectious and parasitic diseases RC109-216 Sujit Pujhari Jason L Rasgon Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
description	Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
format	article
author	Sujit Pujhari Jason L Rasgon
author_facet	Sujit Pujhari Jason L Rasgon
author_sort	Sujit Pujhari
title	Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_short	Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_full	Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_fullStr	Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_full_unstemmed	Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_sort	mice with humanized-lungs and immune system - an idealized model for covid-19 and other respiratory illness
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/f4fb78db164c4e9dbed23e6a1ef87de1
work_keys_str_mv	AT sujitpujhari micewithhumanizedlungsandimmunesystemanidealizedmodelforcovid19andotherrespiratoryillness AT jasonlrasgon micewithhumanizedlungsandimmunesystemanidealizedmodelforcovid19andotherrespiratoryillness
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Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

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