α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation a...

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Autores principales:	Kizhakke M. Sathyan, Daniele Fachinetti, Daniel R. Foltz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4fd7f8ba942491ca6ad29bb5cdc3151
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spelling	oai:doaj.org-article:f4fd7f8ba942491ca6ad29bb5cdc31512021-12-02T17:01:19Zα-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere10.1038/ncomms146782041-1723https://doaj.org/article/f4fd7f8ba942491ca6ad29bb5cdc31512017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14678https://doaj.org/toc/2041-1723Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation and cell survival.Kizhakke M. SathyanDaniele FachinettiDaniel R. FoltzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kizhakke M. Sathyan Daniele Fachinetti Daniel R. Foltz α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
description	Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation and cell survival.
format	article
author	Kizhakke M. Sathyan Daniele Fachinetti Daniel R. Foltz
author_facet	Kizhakke M. Sathyan Daniele Fachinetti Daniel R. Foltz
author_sort	Kizhakke M. Sathyan
title	α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
title_short	α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
title_full	α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
title_fullStr	α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
title_full_unstemmed	α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
title_sort	α-amino trimethylation of cenp-a by nrmt is required for full recruitment of the centromere
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f4fd7f8ba942491ca6ad29bb5cdc3151
work_keys_str_mv	AT kizhakkemsathyan aaminotrimethylationofcenpabynrmtisrequiredforfullrecruitmentofthecentromere AT danielefachinetti aaminotrimethylationofcenpabynrmtisrequiredforfullrecruitmentofthecentromere AT danielrfoltz aaminotrimethylationofcenpabynrmtisrequiredforfullrecruitmentofthecentromere
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α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

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