α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation a...

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Autores principales: Kizhakke M. Sathyan, Daniele Fachinetti, Daniel R. Foltz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/f4fd7f8ba942491ca6ad29bb5cdc3151
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