Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress

Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy is cardiac mitochondrial dysfunction. The cardiac mitochondrial dysfunction can induce oxidative stress in cardiomyocyt...

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Autores principales:	Syaifuzah Sapian, Izatus Shima Taib, Jalifah Latip, Haliza Katas, Kok-Yong Chin, Nor Anizah Mohd Nor, Fatin Farhana Jubaidi, Siti Balkis Budin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavone flavanone flavonol flavanol isoflavone anthocyanin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f5009bd69ead4f6496fd8871129bd5dd
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spelling	oai:doaj.org-article:f5009bd69ead4f6496fd8871129bd5dd2021-11-11T17:05:40ZTherapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress10.3390/ijms2221116161422-00671661-6596https://doaj.org/article/f5009bd69ead4f6496fd8871129bd5dd2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11616https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy is cardiac mitochondrial dysfunction. The cardiac mitochondrial dysfunction can induce oxidative stress in cardiomyocytes and was found to be the cause of majority of the heart morphological and dynamical changes in diabetic cardiomyopathy. To slow down the occurrence of diabetic cardiomyopathy, it is crucial to discover therapeutic agents that target mitochondrial-induced oxidative stress. Flavonoid is a plentiful phytochemical in plants that shows a wide range of biological actions against human diseases. Flavonoids have been extensively documented for their ability to protect the heart from diabetic cardiomyopathy. Flavonoids’ ability to alleviate diabetic cardiomyopathy is primarily attributed to their antioxidant properties. In this review, we present the mechanisms involved in flavonoid therapies in ameliorating mitochondrial-induced oxidative stress in diabetic cardiomyopathy.Syaifuzah SapianIzatus Shima TaibJalifah LatipHaliza KatasKok-Yong ChinNor Anizah Mohd NorFatin Farhana JubaidiSiti Balkis BudinMDPI AGarticleflavoneflavanoneflavonolflavanolisoflavoneanthocyaninBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11616, p 11616 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavone flavanone flavonol flavanol isoflavone anthocyanin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	flavone flavanone flavonol flavanol isoflavone anthocyanin Biology (General) QH301-705.5 Chemistry QD1-999 Syaifuzah Sapian Izatus Shima Taib Jalifah Latip Haliza Katas Kok-Yong Chin Nor Anizah Mohd Nor Fatin Farhana Jubaidi Siti Balkis Budin Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
description	Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy is cardiac mitochondrial dysfunction. The cardiac mitochondrial dysfunction can induce oxidative stress in cardiomyocytes and was found to be the cause of majority of the heart morphological and dynamical changes in diabetic cardiomyopathy. To slow down the occurrence of diabetic cardiomyopathy, it is crucial to discover therapeutic agents that target mitochondrial-induced oxidative stress. Flavonoid is a plentiful phytochemical in plants that shows a wide range of biological actions against human diseases. Flavonoids have been extensively documented for their ability to protect the heart from diabetic cardiomyopathy. Flavonoids’ ability to alleviate diabetic cardiomyopathy is primarily attributed to their antioxidant properties. In this review, we present the mechanisms involved in flavonoid therapies in ameliorating mitochondrial-induced oxidative stress in diabetic cardiomyopathy.
format	article
author	Syaifuzah Sapian Izatus Shima Taib Jalifah Latip Haliza Katas Kok-Yong Chin Nor Anizah Mohd Nor Fatin Farhana Jubaidi Siti Balkis Budin
author_facet	Syaifuzah Sapian Izatus Shima Taib Jalifah Latip Haliza Katas Kok-Yong Chin Nor Anizah Mohd Nor Fatin Farhana Jubaidi Siti Balkis Budin
author_sort	Syaifuzah Sapian
title	Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
title_short	Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
title_full	Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
title_fullStr	Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
title_full_unstemmed	Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress
title_sort	therapeutic approach of flavonoid in ameliorating diabetic cardiomyopathy by targeting mitochondrial-induced oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f5009bd69ead4f6496fd8871129bd5dd
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Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress

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