A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems

A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems

Kholoud E Albinali,1 Moustafa M Zagho,1 Yonghui Deng,2 Ahmed A Elzatahry1 1Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Albinali KE, Zagho MM, Deng Y, Elzatahry AA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
magnetic
mesoporous
core-shell
drug carriers
controlled release
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/f504899e6f0f4f448e9a4c23210c8ce9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f504899e6f0f4f448e9a4c23210c8ce9
record_format dspace
spelling oai:doaj.org-article:f504899e6f0f4f448e9a4c23210c8ce92021-12-02T03:01:19ZA perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems1178-2013https://doaj.org/article/f504899e6f0f4f448e9a4c23210c8ce92019-03-01T00:00:00Zhttps://www.dovepress.com/a-perspective-on-magnetic-core-shell-carriers-for-responsive-and-targe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kholoud E Albinali,1 Moustafa M Zagho,1 Yonghui Deng,2 Ahmed A Elzatahry1 1Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai, People’s Republic of China Abstract: Magnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe2O3 and Fe3O4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment. Keywords: magnetic, mesoporous, core–shell, drug carriers, active targeting, passive targeting, controlled release, targeted cancer treatmentAlbinali KEZagho MMDeng YElzatahry AADove Medical Pressarticlemagneticmesoporouscore-shelldrug carrierscontrolled releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1707-1723 (2019)
institution DOAJ
collection DOAJ
language EN
topic magnetic
mesoporous
core-shell
drug carriers
controlled release
Medicine (General)
R5-920
spellingShingle magnetic
mesoporous
core-shell
drug carriers
controlled release
Medicine (General)
R5-920
Albinali KE
Zagho MM
Deng Y
Elzatahry AA
A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
description Kholoud E Albinali,1 Moustafa M Zagho,1 Yonghui Deng,2 Ahmed A Elzatahry1 1Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar; 2Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai, People’s Republic of China Abstract: Magnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe2O3 and Fe3O4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment. Keywords: magnetic, mesoporous, core–shell, drug carriers, active targeting, passive targeting, controlled release, targeted cancer treatment
format article
author Albinali KE
Zagho MM
Deng Y
Elzatahry AA
author_facet Albinali KE
Zagho MM
Deng Y
Elzatahry AA
author_sort Albinali KE
title A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
title_short A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
title_full A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
title_fullStr A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
title_full_unstemmed A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
title_sort perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/f504899e6f0f4f448e9a4c23210c8ce9
work_keys_str_mv AT albinalike aperspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT zaghomm aperspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT dengy aperspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT elzatahryaa aperspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT albinalike perspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT zaghomm perspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT dengy perspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
AT elzatahryaa perspectiveonmagneticcorendashshellcarriersforresponsiveandtargeteddrugdeliverysystems
_version_ 1718402017171341312

Ejemplares similares