The effect of air pollution on the transcriptomics of the immune response to respiratory infection

Abstract Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized that increased concentrations of combustion related PM would result in...

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Autores principales:	Daniel P. Croft, David S. Burton, David J. Nagel, Soumyaroop Bhattacharya, Ann R. Falsey, Steve N. Georas, Philip K. Hopke, Carl J. Johnston, R. Matthew Kottmann, Augusto A. Litonjua, Thomas J. Mariani, David Q. Rich, Kelly Thevenet-Morrison, Sally W. Thurston, Mark J. Utell, Matthew N. McCall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f504fe72eea34f34b71bf81db1a6ebe3
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spelling	oai:doaj.org-article:f504fe72eea34f34b71bf81db1a6ebe32021-12-02T19:16:59ZThe effect of air pollution on the transcriptomics of the immune response to respiratory infection10.1038/s41598-021-98729-82045-2322https://doaj.org/article/f504fe72eea34f34b71bf81db1a6ebe32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98729-8https://doaj.org/toc/2045-2322Abstract Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized that increased concentrations of combustion related PM would result in dysregulation of the innate immune system. This epidemiological study includes 111 adult patients hospitalized with respiratory infections who underwent transcriptional analysis of their peripheral blood. We examined the association between gene expression at the time of hospitalization and ambient measurements of particulate air pollutants in the 28 days prior to hospitalization. For each pollutant and time lag, gene-specific linear models adjusting for infection type were fit using LIMMA (Linear Models For Microarray Data), and pathway/gene set analyses were performed using the CAMERA (Correlation Adjusted Mean Rank) program. Comparing patients with viral and/or bacterial infection, the expression patterns associated with air pollution exposure differed. Adjusting for the type of infection, increased concentrations of Delta-C (a marker of biomass smoke) and other PM were associated with upregulation of iron homeostasis and protein folding. Increased concentrations of black carbon (BC) were associated with upregulation of viral related gene pathways and downregulation of pathways related to antigen presentation. The pollutant/pathway associations differed by lag time and by type of infection. This study suggests that the effect of air pollution on the pathogenesis of respiratory infection may be pollutant, timing, and infection specific.Daniel P. CroftDavid S. BurtonDavid J. NagelSoumyaroop BhattacharyaAnn R. FalseySteve N. GeorasPhilip K. HopkeCarl J. JohnstonR. Matthew KottmannAugusto A. LitonjuaThomas J. MarianiDavid Q. RichKelly Thevenet-MorrisonSally W. ThurstonMark J. UtellMatthew N. McCallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel P. Croft David S. Burton David J. Nagel Soumyaroop Bhattacharya Ann R. Falsey Steve N. Georas Philip K. Hopke Carl J. Johnston R. Matthew Kottmann Augusto A. Litonjua Thomas J. Mariani David Q. Rich Kelly Thevenet-Morrison Sally W. Thurston Mark J. Utell Matthew N. McCall The effect of air pollution on the transcriptomics of the immune response to respiratory infection
description	Abstract Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized that increased concentrations of combustion related PM would result in dysregulation of the innate immune system. This epidemiological study includes 111 adult patients hospitalized with respiratory infections who underwent transcriptional analysis of their peripheral blood. We examined the association between gene expression at the time of hospitalization and ambient measurements of particulate air pollutants in the 28 days prior to hospitalization. For each pollutant and time lag, gene-specific linear models adjusting for infection type were fit using LIMMA (Linear Models For Microarray Data), and pathway/gene set analyses were performed using the CAMERA (Correlation Adjusted Mean Rank) program. Comparing patients with viral and/or bacterial infection, the expression patterns associated with air pollution exposure differed. Adjusting for the type of infection, increased concentrations of Delta-C (a marker of biomass smoke) and other PM were associated with upregulation of iron homeostasis and protein folding. Increased concentrations of black carbon (BC) were associated with upregulation of viral related gene pathways and downregulation of pathways related to antigen presentation. The pollutant/pathway associations differed by lag time and by type of infection. This study suggests that the effect of air pollution on the pathogenesis of respiratory infection may be pollutant, timing, and infection specific.
format	article
author	Daniel P. Croft David S. Burton David J. Nagel Soumyaroop Bhattacharya Ann R. Falsey Steve N. Georas Philip K. Hopke Carl J. Johnston R. Matthew Kottmann Augusto A. Litonjua Thomas J. Mariani David Q. Rich Kelly Thevenet-Morrison Sally W. Thurston Mark J. Utell Matthew N. McCall
author_facet	Daniel P. Croft David S. Burton David J. Nagel Soumyaroop Bhattacharya Ann R. Falsey Steve N. Georas Philip K. Hopke Carl J. Johnston R. Matthew Kottmann Augusto A. Litonjua Thomas J. Mariani David Q. Rich Kelly Thevenet-Morrison Sally W. Thurston Mark J. Utell Matthew N. McCall
author_sort	Daniel P. Croft
title	The effect of air pollution on the transcriptomics of the immune response to respiratory infection
title_short	The effect of air pollution on the transcriptomics of the immune response to respiratory infection
title_full	The effect of air pollution on the transcriptomics of the immune response to respiratory infection
title_fullStr	The effect of air pollution on the transcriptomics of the immune response to respiratory infection
title_full_unstemmed	The effect of air pollution on the transcriptomics of the immune response to respiratory infection
title_sort	effect of air pollution on the transcriptomics of the immune response to respiratory infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f504fe72eea34f34b71bf81db1a6ebe3
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The effect of air pollution on the transcriptomics of the immune response to respiratory infection

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