The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche

Abstract Smart biomaterials are increasingly being used to control stem cell fate in vitro by the recapitulation of the native niche microenvironment. By integrating experimental measurements with numerical models, we show that in mesenchymal stem cells grown inside a 3D synthetic niche both nuclear...

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Autores principales: Emanuela Jacchetti, Ramin Nasehi, Lucia Boeri, Valentina Parodi, Alessandro Negro, Diego Albani, Roberto Osellame, Giulio Cerullo, Jose Felix Rodriguez Matas, Manuela Teresa Raimondi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f506a71168f74e929134b61056b23a77
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