Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A.

<h4>Background</h4>Phosphodiesterases (PDEs) cleave phosphodiester bonds in cyclic nucleotides and play diverse roles in cell biology. PDE5A is a cytoplasmic phosphodiesterase which specifically degrades cyclic guanosine monophosphate (cGMP), a cell signaling molecule that plays importan...

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Bibliographic Details
Main Authors: Julie Carøe Nordgaard, Lars Schack Kruse, Steen Gammeltoft, Christina Rostrup Kruuse
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
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Online Access:https://doaj.org/article/f50aa976ce4248b6b5e99ad2e06f2210
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