The switch of DNA states filtering the extrinsic noise in the system of frequency modulation

Abstract There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circ...

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Autores principales:	Shih-Chiang Lo, Chao-Xuan You, Bo-Ren Chen, Ching-Chu Hsieh, Cheng-En Li, Che-Chi Shu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f50d5df7e04d4ee39f134095acc97d95
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spelling	oai:doaj.org-article:f50d5df7e04d4ee39f134095acc97d952021-12-02T15:08:11ZThe switch of DNA states filtering the extrinsic noise in the system of frequency modulation10.1038/s41598-021-95365-02045-2322https://doaj.org/article/f50d5df7e04d4ee39f134095acc97d952021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95365-0https://doaj.org/toc/2045-2322Abstract There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.Shih-Chiang LoChao-Xuan YouBo-Ren ChenChing-Chu HsiehCheng-En LiChe-Chi ShuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shih-Chiang Lo Chao-Xuan You Bo-Ren Chen Ching-Chu Hsieh Cheng-En Li Che-Chi Shu The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
description	Abstract There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.
format	article
author	Shih-Chiang Lo Chao-Xuan You Bo-Ren Chen Ching-Chu Hsieh Cheng-En Li Che-Chi Shu
author_facet	Shih-Chiang Lo Chao-Xuan You Bo-Ren Chen Ching-Chu Hsieh Cheng-En Li Che-Chi Shu
author_sort	Shih-Chiang Lo
title	The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_short	The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_full	The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_fullStr	The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_full_unstemmed	The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_sort	switch of dna states filtering the extrinsic noise in the system of frequency modulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f50d5df7e04d4ee39f134095acc97d95
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The switch of DNA states filtering the extrinsic noise in the system of frequency modulation

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