Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation

Yekta Dowlati,1,2 Danilo R de Jesus,1,2 Peter Selby,1–3 Ian Fan,2,4 Jeffrey H Meyer1,2 1CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; 2Department of Psychiatry, University of Toronto, Toronto,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dowlati Y, de Jesus DR, Selby P, Fan I, Meyer JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cigarette withdrawal dysphoria dietary supplement mood induction monoamines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f50da600911441fdadfd628c840720e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f50da600911441fdadfd628c840720e7
record_format	dspace
spelling	oai:doaj.org-article:f50da600911441fdadfd628c840720e72021-12-02T01:48:38ZDepressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation1178-2021https://doaj.org/article/f50da600911441fdadfd628c840720e72019-01-01T00:00:00Zhttps://www.dovepress.com/depressed-mood-induction-in-early-cigarette-withdrawal-is-unaffected-b-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yekta Dowlati,1,2 Danilo R de Jesus,1,2 Peter Selby,1–3 Ian Fan,2,4 Jeffrey H Meyer1,2 1CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; 2Department of Psychiatry, University of Toronto, Toronto, ON, Canada; 3Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; 4Mood Disorders Association of British Columbia, Vancouver, BC, Canada Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Hence, we conducted a randomized, placebo-controlled, double-blind crossover trial of a dietary supplement designed to counter the effects of elevated MAO-A levels on vulnerability to depressed mood.Methods: Twenty-one otherwise healthy cigarette smokers completed the protocol, receiving either active dietary supplement followed by washout and placebo or the same in reverse order. The dietary supplement was composed of monoamine precursors (2 g tryptophan, 10 g tyrosine) and blueberry antioxidants (blueberry juice with blueberry extract). Vulnerability to depressed mood was measured by the change in scores of depressed mood on the visual analog scale (VAS) following the sad mood induction paradigm (MIP).Results: There was a significant increase in VAS depressed mood scores after the sad MIP during supplement and placebo, but no difference between active and placebo conditions. There was also a significant increase in urge-to-smoke scores after sad MIP during supplement and placebo but no difference between active and placebo conditions. Reliability of the increase in VAS after MIP was very good.Conclusion: The dietary supplement had negligible effect on depressed mood, but sad MIP is a very reliable method that can be applied in future studies to assess other interventions for preventing dysphoric mood during early cigarette withdrawal.  Keywords: cigarette withdrawal, dysphoria, dietary supplement, mood induction, monoaminesDowlati Yde Jesus DRSelby PFan IMeyer JHDove Medical PressarticleCigarette withdrawaldysphoriadietary supplementmood inductionmonoaminesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 311-321 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cigarette withdrawal dysphoria dietary supplement mood induction monoamines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cigarette withdrawal dysphoria dietary supplement mood induction monoamines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dowlati Y de Jesus DR Selby P Fan I Meyer JH Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
description	Yekta Dowlati,1,2 Danilo R de Jesus,1,2 Peter Selby,1–3 Ian Fan,2,4 Jeffrey H Meyer1,2 1CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; 2Department of Psychiatry, University of Toronto, Toronto, ON, Canada; 3Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; 4Mood Disorders Association of British Columbia, Vancouver, BC, Canada Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Hence, we conducted a randomized, placebo-controlled, double-blind crossover trial of a dietary supplement designed to counter the effects of elevated MAO-A levels on vulnerability to depressed mood.Methods: Twenty-one otherwise healthy cigarette smokers completed the protocol, receiving either active dietary supplement followed by washout and placebo or the same in reverse order. The dietary supplement was composed of monoamine precursors (2 g tryptophan, 10 g tyrosine) and blueberry antioxidants (blueberry juice with blueberry extract). Vulnerability to depressed mood was measured by the change in scores of depressed mood on the visual analog scale (VAS) following the sad mood induction paradigm (MIP).Results: There was a significant increase in VAS depressed mood scores after the sad MIP during supplement and placebo, but no difference between active and placebo conditions. There was also a significant increase in urge-to-smoke scores after sad MIP during supplement and placebo but no difference between active and placebo conditions. Reliability of the increase in VAS after MIP was very good.Conclusion: The dietary supplement had negligible effect on depressed mood, but sad MIP is a very reliable method that can be applied in future studies to assess other interventions for preventing dysphoric mood during early cigarette withdrawal.  Keywords: cigarette withdrawal, dysphoria, dietary supplement, mood induction, monoamines
format	article
author	Dowlati Y de Jesus DR Selby P Fan I Meyer JH
author_facet	Dowlati Y de Jesus DR Selby P Fan I Meyer JH
author_sort	Dowlati Y
title	Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
title_short	Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
title_full	Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
title_fullStr	Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
title_full_unstemmed	Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
title_sort	depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f50da600911441fdadfd628c840720e7
work_keys_str_mv	AT dowlatiy depressedmoodinductioninearlycigarettewithdrawalisunaffectedbyacutemonoamineprecursorsupplementation AT dejesusdr depressedmoodinductioninearlycigarettewithdrawalisunaffectedbyacutemonoamineprecursorsupplementation AT selbyp depressedmoodinductioninearlycigarettewithdrawalisunaffectedbyacutemonoamineprecursorsupplementation AT fani depressedmoodinductioninearlycigarettewithdrawalisunaffectedbyacutemonoamineprecursorsupplementation AT meyerjh depressedmoodinductioninearlycigarettewithdrawalisunaffectedbyacutemonoamineprecursorsupplementation
_version_	1718402933344698368

Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation

Ejemplares similares