Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit

Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in the central amygdala is involved in the early fear...

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Autores principales:	Yong S. Jo, Vijay Mohan K. Namboodiri, Garret D. Stuber, Larry S. Zweifel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f50f1c98dcf546afbe56dc8a475cedea
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spelling	oai:doaj.org-article:f50f1c98dcf546afbe56dc8a475cedea2021-12-02T14:40:51ZPersistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit10.1038/s41467-020-14393-y2041-1723https://doaj.org/article/f50f1c98dcf546afbe56dc8a475cedea2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14393-yhttps://doaj.org/toc/2041-1723Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in the central amygdala is involved in the early fear extinction deficit.Yong S. JoVijay Mohan K. NamboodiriGarret D. StuberLarry S. ZweifelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong S. Jo Vijay Mohan K. Namboodiri Garret D. Stuber Larry S. Zweifel Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
description	Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in the central amygdala is involved in the early fear extinction deficit.
format	article
author	Yong S. Jo Vijay Mohan K. Namboodiri Garret D. Stuber Larry S. Zweifel
author_facet	Yong S. Jo Vijay Mohan K. Namboodiri Garret D. Stuber Larry S. Zweifel
author_sort	Yong S. Jo
title	Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
title_short	Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
title_full	Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
title_fullStr	Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
title_full_unstemmed	Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit
title_sort	persistent activation of central amygdala crf neurons helps drive the immediate fear extinction deficit
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f50f1c98dcf546afbe56dc8a475cedea
work_keys_str_mv	AT yongsjo persistentactivationofcentralamygdalacrfneuronshelpsdrivetheimmediatefearextinctiondeficit AT vijaymohanknamboodiri persistentactivationofcentralamygdalacrfneuronshelpsdrivetheimmediatefearextinctiondeficit AT garretdstuber persistentactivationofcentralamygdalacrfneuronshelpsdrivetheimmediatefearextinctiondeficit AT larryszweifel persistentactivationofcentralamygdalacrfneuronshelpsdrivetheimmediatefearextinctiondeficit
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Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit

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