Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma

Abstract Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success. Systems biology appr...

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Autores principales:	Hassan Rakhsh-Khorshid, Hilda Samimi, Shukoofeh Torabi, Sayed Mahmoud Sajjadi-Jazi, Hamed Samadi, Fatemeh Ghafouri, Yazdan Asgari, Vahid Haghpanah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f50f925af0f04de69b5a8136a92662d7
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spelling	oai:doaj.org-article:f50f925af0f04de69b5a8136a92662d72021-12-02T11:43:43ZNetwork analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma10.1038/s41598-020-78574-x2045-2322https://doaj.org/article/f50f925af0f04de69b5a8136a92662d72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78574-xhttps://doaj.org/toc/2045-2322Abstract Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success. Systems biology approaches have been used to simplify complex biological networks. Here, we attempt to find more suitable targets in order to restore NIS expression in ATC cells. We have built a simplified protein interaction network including transcription factors and proteins involved in MAPK, TGFβ/SMAD, PI3K/AKT, and TSHR signaling pathways which regulate NIS expression, alongside proteins interacting with them. The network was analyzed, and proteins were ranked based on several centrality indices. Our results suggest that the protein interaction network of NIS expression regulation is modular, and distance-based and information-flow-based centrality indices may be better predictors of important proteins in such networks. We propose that the high-ranked proteins found in our analysis are expected to be more promising targets in attempts to restore NIS expression in ATC cells.Hassan Rakhsh-KhorshidHilda SamimiShukoofeh TorabiSayed Mahmoud Sajjadi-JaziHamed SamadiFatemeh GhafouriYazdan AsgariVahid HaghpanahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hassan Rakhsh-Khorshid Hilda Samimi Shukoofeh Torabi Sayed Mahmoud Sajjadi-Jazi Hamed Samadi Fatemeh Ghafouri Yazdan Asgari Vahid Haghpanah Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
description	Abstract Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success. Systems biology approaches have been used to simplify complex biological networks. Here, we attempt to find more suitable targets in order to restore NIS expression in ATC cells. We have built a simplified protein interaction network including transcription factors and proteins involved in MAPK, TGFβ/SMAD, PI3K/AKT, and TSHR signaling pathways which regulate NIS expression, alongside proteins interacting with them. The network was analyzed, and proteins were ranked based on several centrality indices. Our results suggest that the protein interaction network of NIS expression regulation is modular, and distance-based and information-flow-based centrality indices may be better predictors of important proteins in such networks. We propose that the high-ranked proteins found in our analysis are expected to be more promising targets in attempts to restore NIS expression in ATC cells.
format	article
author	Hassan Rakhsh-Khorshid Hilda Samimi Shukoofeh Torabi Sayed Mahmoud Sajjadi-Jazi Hamed Samadi Fatemeh Ghafouri Yazdan Asgari Vahid Haghpanah
author_facet	Hassan Rakhsh-Khorshid Hilda Samimi Shukoofeh Torabi Sayed Mahmoud Sajjadi-Jazi Hamed Samadi Fatemeh Ghafouri Yazdan Asgari Vahid Haghpanah
author_sort	Hassan Rakhsh-Khorshid
title	Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
title_short	Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
title_full	Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
title_fullStr	Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
title_full_unstemmed	Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
title_sort	network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f50f925af0f04de69b5a8136a92662d7
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Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma

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