Human adenovirus species C recombinant virus continuously circulated in China

Abstract To date, at least three lineages (Lineage 1–3) that are related to recombinant human adenovirus species C (HAdV-C) have been identified in China. Among them, Lineage 1 includes two Chinese strains, strain KR699642-CHN-20093 (CBJ11) and strain MF315029-CHN-2013 (BJ09), which were collected i...

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Autores principales:	Jianfang Yang, Naiying Mao, Chuangye Zhang, Binzhi Ren, Hong Li, Na Li, Jing Chen, Ruifu Zhang, Zhen Zhu, Wenbo Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f51096cc6d6b44de8abaf349174bebbb
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spelling	oai:doaj.org-article:f51096cc6d6b44de8abaf349174bebbb2021-12-02T15:09:33ZHuman adenovirus species C recombinant virus continuously circulated in China10.1038/s41598-019-46228-22045-2322https://doaj.org/article/f51096cc6d6b44de8abaf349174bebbb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46228-2https://doaj.org/toc/2045-2322Abstract To date, at least three lineages (Lineage 1–3) that are related to recombinant human adenovirus species C (HAdV-C) have been identified in China. Among them, Lineage 1 includes two Chinese strains, strain KR699642-CHN-20093 (CBJ11) and strain MF315029-CHN-2013 (BJ09), which were collected in Beijing in 2009 and 2013, respectively. Herein, we performed genomic and bioinformatics analysis of two HAdV-C strains (strain SX-2000-140 and strain SX-2004-327) that were isolated from the feces of two healthy children in Shanxi province of China in 2000 and 2004, respectively. Results revealed that the genomes of both Shanxi strains had the highest homology to two Chinese HAdV-C strains belonging to Lineage 1 and harbored the genetic elements of these two strains, thereby presuming that Lineage1 has been circulated in mainland of China for decades. In addition, though the viruses in Lineage 1 showed slightly different recombinant patterns resulting from the recombinant events among the five types of HAdV-C, all the Lineage 1 viruses shared the highest sequence similarities with the HAdV-2 prototype strain (NC_001405-USA-1953) across the genome, especially in the major capsid genes including hexon, and fiber. These results indicated that Lineage 1 viruses that were associated with recombinants shared a common ancestor that is closely related to the HAdV-2 virus. Our current findings confirmed that frequent recombination among the different HAdV-C types might be an important driving force for the molecular evolution of HAdV-C. Therefore, there is a strong need for further comprehensive and systematic monitoring, detection, and research on HAdV-C.Jianfang YangNaiying MaoChuangye ZhangBinzhi RenHong LiNa LiJing ChenRuifu ZhangHong LiZhen ZhuWenbo XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianfang Yang Naiying Mao Chuangye Zhang Binzhi Ren Hong Li Na Li Jing Chen Ruifu Zhang Hong Li Zhen Zhu Wenbo Xu Human adenovirus species C recombinant virus continuously circulated in China
description	Abstract To date, at least three lineages (Lineage 1–3) that are related to recombinant human adenovirus species C (HAdV-C) have been identified in China. Among them, Lineage 1 includes two Chinese strains, strain KR699642-CHN-20093 (CBJ11) and strain MF315029-CHN-2013 (BJ09), which were collected in Beijing in 2009 and 2013, respectively. Herein, we performed genomic and bioinformatics analysis of two HAdV-C strains (strain SX-2000-140 and strain SX-2004-327) that were isolated from the feces of two healthy children in Shanxi province of China in 2000 and 2004, respectively. Results revealed that the genomes of both Shanxi strains had the highest homology to two Chinese HAdV-C strains belonging to Lineage 1 and harbored the genetic elements of these two strains, thereby presuming that Lineage1 has been circulated in mainland of China for decades. In addition, though the viruses in Lineage 1 showed slightly different recombinant patterns resulting from the recombinant events among the five types of HAdV-C, all the Lineage 1 viruses shared the highest sequence similarities with the HAdV-2 prototype strain (NC_001405-USA-1953) across the genome, especially in the major capsid genes including hexon, and fiber. These results indicated that Lineage 1 viruses that were associated with recombinants shared a common ancestor that is closely related to the HAdV-2 virus. Our current findings confirmed that frequent recombination among the different HAdV-C types might be an important driving force for the molecular evolution of HAdV-C. Therefore, there is a strong need for further comprehensive and systematic monitoring, detection, and research on HAdV-C.
format	article
author	Jianfang Yang Naiying Mao Chuangye Zhang Binzhi Ren Hong Li Na Li Jing Chen Ruifu Zhang Hong Li Zhen Zhu Wenbo Xu
author_facet	Jianfang Yang Naiying Mao Chuangye Zhang Binzhi Ren Hong Li Na Li Jing Chen Ruifu Zhang Hong Li Zhen Zhu Wenbo Xu
author_sort	Jianfang Yang
title	Human adenovirus species C recombinant virus continuously circulated in China
title_short	Human adenovirus species C recombinant virus continuously circulated in China
title_full	Human adenovirus species C recombinant virus continuously circulated in China
title_fullStr	Human adenovirus species C recombinant virus continuously circulated in China
title_full_unstemmed	Human adenovirus species C recombinant virus continuously circulated in China
title_sort	human adenovirus species c recombinant virus continuously circulated in china
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f51096cc6d6b44de8abaf349174bebbb
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Human adenovirus species C recombinant virus continuously circulated in China

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