Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AG...

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Autores principales:	David Favre, Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma, Sean Proll, Zeljka Kasakow, Jeff Mold, Louise Swainson, Jason D Barbour, Carole R Baskin, Robert Palermo, Ivona Pandrea, Christopher J Miller, Michael G Katze, Joseph M McCune
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f51263d8f52a4f728d90c832970fefa4
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spelling	oai:doaj.org-article:f51263d8f52a4f728d90c832970fefa42021-11-25T05:47:17ZCritical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.1553-73661553-737410.1371/journal.ppat.1000295https://doaj.org/article/f51263d8f52a4f728d90c832970fefa42009-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19214220/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.David FavreSharon LedererBittoo KanwarZhong-Min MaSean ProllZeljka KasakowJeff MoldLouise SwainsonJason D BarbourCarole R BaskinRobert PalermoIvona PandreaChristopher J MillerMichael G KatzeJoseph M McCunePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 2, p e1000295 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 David Favre Sharon Lederer Bittoo Kanwar Zhong-Min Ma Sean Proll Zeljka Kasakow Jeff Mold Louise Swainson Jason D Barbour Carole R Baskin Robert Palermo Ivona Pandrea Christopher J Miller Michael G Katze Joseph M McCune Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
description	Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.
format	article
author	David Favre Sharon Lederer Bittoo Kanwar Zhong-Min Ma Sean Proll Zeljka Kasakow Jeff Mold Louise Swainson Jason D Barbour Carole R Baskin Robert Palermo Ivona Pandrea Christopher J Miller Michael G Katze Joseph M McCune
author_facet	David Favre Sharon Lederer Bittoo Kanwar Zhong-Min Ma Sean Proll Zeljka Kasakow Jeff Mold Louise Swainson Jason D Barbour Carole R Baskin Robert Palermo Ivona Pandrea Christopher J Miller Michael G Katze Joseph M McCune
author_sort	David Favre
title	Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
title_short	Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
title_full	Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
title_fullStr	Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
title_full_unstemmed	Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
title_sort	critical loss of the balance between th17 and t regulatory cell populations in pathogenic siv infection.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f51263d8f52a4f728d90c832970fefa4
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Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

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