Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

<b>Background</b>: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. <b>Aim</b>: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose ratio (C<sub>0</su...

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Autores principales: Nikola Stefanović, Radmila Veličković-Radovanović, Katarina Danković, Ivan Pavlović, Aleksandra Catić-Đorđević, Jelena Bašić, Milena Despotović, Tatjana Jevtović-Stoimenov, Branka Mitić, Tatjana Cvetković
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
intrapatient variability
kidney transplantation
CYP3A5 genotype
tacrolimus
therapeutic drug monitoring
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/f516b028f4de4006b5ad0a0a02ba1e0b
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https://doaj.org/article/f516b028f4de4006b5ad0a0a02ba1e0b

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