Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.

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Autores principales: Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
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spelling oai:doaj.org-article:f516c8c11d6a41889865f546d8e29a092021-12-02T14:41:21ZCheckpoint kinase 1 is essential for normal B cell development and lymphomagenesis10.1038/s41467-017-01850-42041-1723https://doaj.org/article/f516c8c11d6a41889865f546d8e29a092017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01850-4https://doaj.org/toc/2041-1723Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.Fabian SchulerJohannes G. WeissSilke E. LindnerMichael LohmüllerSebastian HerzogSimon F. SpieglPhilipp MenkeStephan GeleyVerena LabiAndreas VillungerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fabian Schuler
Johannes G. Weiss
Silke E. Lindner
Michael Lohmüller
Sebastian Herzog
Simon F. Spiegl
Philipp Menke
Stephan Geley
Verena Labi
Andreas Villunger
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
description Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.
format article
author Fabian Schuler
Johannes G. Weiss
Silke E. Lindner
Michael Lohmüller
Sebastian Herzog
Simon F. Spiegl
Philipp Menke
Stephan Geley
Verena Labi
Andreas Villunger
author_facet Fabian Schuler
Johannes G. Weiss
Silke E. Lindner
Michael Lohmüller
Sebastian Herzog
Simon F. Spiegl
Philipp Menke
Stephan Geley
Verena Labi
Andreas Villunger
author_sort Fabian Schuler
title Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_short Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_full Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_fullStr Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_full_unstemmed Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_sort checkpoint kinase 1 is essential for normal b cell development and lymphomagenesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
work_keys_str_mv AT fabianschuler checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT johannesgweiss checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT silkeelindner checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT michaellohmuller checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT sebastianherzog checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
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AT philippmenke checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT stephangeley checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT verenalabi checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
AT andreasvillunger checkpointkinase1isessentialfornormalbcelldevelopmentandlymphomagenesis
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