Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.

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Auteurs principaux:	Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
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spelling	oai:doaj.org-article:f516c8c11d6a41889865f546d8e29a092021-12-02T14:41:21ZCheckpoint kinase 1 is essential for normal B cell development and lymphomagenesis10.1038/s41467-017-01850-42041-1723https://doaj.org/article/f516c8c11d6a41889865f546d8e29a092017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01850-4https://doaj.org/toc/2041-1723Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.Fabian SchulerJohannes G. WeissSilke E. LindnerMichael LohmüllerSebastian HerzogSimon F. SpieglPhilipp MenkeStephan GeleyVerena LabiAndreas VillungerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
description	Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.
format	article
author	Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger
author_facet	Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger
author_sort	Fabian Schuler
title	Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_short	Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_full	Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_fullStr	Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_full_unstemmed	Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
title_sort	checkpoint kinase 1 is essential for normal b cell development and lymphomagenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
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_version_	1718389967242133504

Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

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