Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.
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Nature Portfolio
2017
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oai:doaj.org-article:f516c8c11d6a41889865f546d8e29a092021-12-02T14:41:21ZCheckpoint kinase 1 is essential for normal B cell development and lymphomagenesis10.1038/s41467-017-01850-42041-1723https://doaj.org/article/f516c8c11d6a41889865f546d8e29a092017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01850-4https://doaj.org/toc/2041-1723Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.Fabian SchulerJohannes G. WeissSilke E. LindnerMichael LohmüllerSebastian HerzogSimon F. SpieglPhilipp MenkeStephan GeleyVerena LabiAndreas VillungerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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DOAJ |
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Science Q |
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Science Q Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
description |
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival. |
format |
article |
author |
Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger |
author_facet |
Fabian Schuler Johannes G. Weiss Silke E. Lindner Michael Lohmüller Sebastian Herzog Simon F. Spiegl Philipp Menke Stephan Geley Verena Labi Andreas Villunger |
author_sort |
Fabian Schuler |
title |
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
title_short |
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
title_full |
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
title_fullStr |
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
title_full_unstemmed |
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis |
title_sort |
checkpoint kinase 1 is essential for normal b cell development and lymphomagenesis |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09 |
work_keys_str_mv |
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_version_ |
1718389967242133504 |