Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted the...

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Autores principales:	Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f51e8b007adc48feb4f6169ad611de36
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spelling	oai:doaj.org-article:f51e8b007adc48feb4f6169ad611de362021-12-02T15:36:02ZDestabilization of NOXA mRNA as a common resistance mechanism to targeted therapies10.1038/s41467-019-12477-y2041-1723https://doaj.org/article/f51e8b007adc48feb4f6169ad611de362019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12477-yhttps://doaj.org/toc/2041-1723MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted therapies overcomes this resistance.Joan MonteroCécile GstalderDaniel J. KimDorota SadowiczWayne MilesMichael ManosJustin R. CidadoJ. Paul SecristAdriana E. TronKeith FlahertyF. Stephen HodiCharles H. YoonAnthony LetaiDavid E. FisherRizwan HaqNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joan Montero Cécile Gstalder Daniel J. Kim Dorota Sadowicz Wayne Miles Michael Manos Justin R. Cidado J. Paul Secrist Adriana E. Tron Keith Flaherty F. Stephen Hodi Charles H. Yoon Anthony Letai David E. Fisher Rizwan Haq Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
description	MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted therapies overcomes this resistance.
format	article
author	Joan Montero Cécile Gstalder Daniel J. Kim Dorota Sadowicz Wayne Miles Michael Manos Justin R. Cidado J. Paul Secrist Adriana E. Tron Keith Flaherty F. Stephen Hodi Charles H. Yoon Anthony Letai David E. Fisher Rizwan Haq
author_facet	Joan Montero Cécile Gstalder Daniel J. Kim Dorota Sadowicz Wayne Miles Michael Manos Justin R. Cidado J. Paul Secrist Adriana E. Tron Keith Flaherty F. Stephen Hodi Charles H. Yoon Anthony Letai David E. Fisher Rizwan Haq
author_sort	Joan Montero
title	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
title_short	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
title_full	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
title_fullStr	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
title_full_unstemmed	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
title_sort	destabilization of noxa mrna as a common resistance mechanism to targeted therapies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f51e8b007adc48feb4f6169ad611de36
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Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

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