The effect of congenital blindness on resting-state functional connectivity revisited

Abstract Lower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed rela...

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Autores principales:	Maria J. S. Guerreiro, Madita Linke, Sunitha Lingareddy, Ramesh Kekunnaya, Brigitte Röder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f52d2abb516b4ecfb255b0b536ad2056
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spelling	oai:doaj.org-article:f52d2abb516b4ecfb255b0b536ad20562021-12-02T17:23:16ZThe effect of congenital blindness on resting-state functional connectivity revisited10.1038/s41598-021-91976-92045-2322https://doaj.org/article/f52d2abb516b4ecfb255b0b536ad20562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91976-9https://doaj.org/toc/2045-2322Abstract Lower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.Maria J. S. GuerreiroMadita LinkeSunitha LingareddyRamesh KekunnayaBrigitte RöderNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria J. S. Guerreiro Madita Linke Sunitha Lingareddy Ramesh Kekunnaya Brigitte Röder The effect of congenital blindness on resting-state functional connectivity revisited
description	Abstract Lower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.
format	article
author	Maria J. S. Guerreiro Madita Linke Sunitha Lingareddy Ramesh Kekunnaya Brigitte Röder
author_facet	Maria J. S. Guerreiro Madita Linke Sunitha Lingareddy Ramesh Kekunnaya Brigitte Röder
author_sort	Maria J. S. Guerreiro
title	The effect of congenital blindness on resting-state functional connectivity revisited
title_short	The effect of congenital blindness on resting-state functional connectivity revisited
title_full	The effect of congenital blindness on resting-state functional connectivity revisited
title_fullStr	The effect of congenital blindness on resting-state functional connectivity revisited
title_full_unstemmed	The effect of congenital blindness on resting-state functional connectivity revisited
title_sort	effect of congenital blindness on resting-state functional connectivity revisited
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f52d2abb516b4ecfb255b0b536ad2056
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The effect of congenital blindness on resting-state functional connectivity revisited

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