Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer

Blanca Murillo-Ortiz,1 Sandra Martínez-Garza,1 Vanessa Cárdenas Landeros,1 Gerardo Cano Velázquez,1 David Suárez García2 1Clinical Epidemiology Research Unit, 2Department of Oncology, Mexican Institute of Social Security, Leon, Mexico I...

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Autores principales:	Murillo-Ortiz B, Martínez-Garza S, Cárdenas Landeros V, Cano Velázquez G, Suárez Garcia D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Breast Cancer BMI Estradiol Adiponectin IGF 1. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f52d325fea3f413fb69d767f0c123959
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spelling	oai:doaj.org-article:f52d325fea3f413fb69d767f0c1239592021-12-02T02:03:37ZEffect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer1179-1314https://doaj.org/article/f52d325fea3f413fb69d767f0c1239592017-05-01T00:00:00Zhttps://www.dovepress.com/effect-of-reduced-dietary-fat-on-estradiol-adiponectin-and-igf-1-level-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Blanca Murillo-Ortiz,1 Sandra Martínez-Garza,1 Vanessa Cárdenas Landeros,1 Gerardo Cano Velázquez,1 David Suárez García2 1Clinical Epidemiology Research Unit, 2Department of Oncology, Mexican Institute of Social Security, Leon, Mexico Introduction: In recent years, epidemiological studies have strongly related obesity with an increased risk of developing postmenopausal breast cancer. The aromatization of fatty tissue increases the levels of estradiol and adiponectin, which is correlated with the body mass index (BMI). It is of interest to investigate the effect of reducing BMI on estradiol, adiponectin, and IGF-1, as reducing BMI could be a new strategy to limit the risk of recurrence during the adjuvant treatment of breast cancer.Objective: The aim of this study is to investigate the effect of reduced dietary fat on the levels of serum estradiol, adiponectin, and IGF-1 among postmenopausal Mexican women with breast cancer.Methods: In this controlled clinical trial, 100 female patients were randomly divided into two groups and followed for six months. Group 1 (n = 50) was subjected to reduced dietary fat, whereas Group 2 (n = 50) was subjected to a control diet. The levels of serum estradiol and testosterone were determined using an enzyme-linked immunosorbent assay, whereas the concentrations of adiponectin and IGF-1 were determined using a radioimmunoassay.Results: The patients subjected to reduced dietary fat showed a significant difference in BMI (27.93 ± 4.45 vs 26.05 ± 2.65; p = 0.01) and waist circumference (99.92 vs 91.59 cm; p = 0.0001) after the treatment. Moreover, a significant decrease in serum estradiol was observed (21.23 ± 14.32 vs 16.05 ± 10.25 ng/mL; p < 0.001). The adiponectin concentration also decreased significantly (47.53 ± 12.19 vs 42.52 ± 12.34 µg/mL; p = 0.004), while IGF-1 and testosterone did not show significant changes (p > 0.05). In addition, BMI had a relationship with serum adiponectin (r = −0.27; p = 0.02) and estradiol (r = 0.37; p = 0.001).Conclusion: The current study shows that reducing BMI decreases serum estradiol and adiponectin. Large clinical trials are needed to investigate the role of adiponectin in breast cancer development in obese women. Keywords: reduced dietary fat, breast cancer, hormone levelsMurillo-Ortiz BMartínez-Garza SCárdenas Landeros VCano Velázquez GSuárez Garcia DDove Medical PressarticleBreast CancerBMIEstradiolAdiponectinIGF 1.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 359-364 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast Cancer BMI Estradiol Adiponectin IGF 1. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast Cancer BMI Estradiol Adiponectin IGF 1. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Murillo-Ortiz B Martínez-Garza S Cárdenas Landeros V Cano Velázquez G Suárez Garcia D Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
description	Blanca Murillo-Ortiz,1 Sandra Martínez-Garza,1 Vanessa Cárdenas Landeros,1 Gerardo Cano Velázquez,1 David Suárez García2 1Clinical Epidemiology Research Unit, 2Department of Oncology, Mexican Institute of Social Security, Leon, Mexico Introduction: In recent years, epidemiological studies have strongly related obesity with an increased risk of developing postmenopausal breast cancer. The aromatization of fatty tissue increases the levels of estradiol and adiponectin, which is correlated with the body mass index (BMI). It is of interest to investigate the effect of reducing BMI on estradiol, adiponectin, and IGF-1, as reducing BMI could be a new strategy to limit the risk of recurrence during the adjuvant treatment of breast cancer.Objective: The aim of this study is to investigate the effect of reduced dietary fat on the levels of serum estradiol, adiponectin, and IGF-1 among postmenopausal Mexican women with breast cancer.Methods: In this controlled clinical trial, 100 female patients were randomly divided into two groups and followed for six months. Group 1 (n = 50) was subjected to reduced dietary fat, whereas Group 2 (n = 50) was subjected to a control diet. The levels of serum estradiol and testosterone were determined using an enzyme-linked immunosorbent assay, whereas the concentrations of adiponectin and IGF-1 were determined using a radioimmunoassay.Results: The patients subjected to reduced dietary fat showed a significant difference in BMI (27.93 ± 4.45 vs 26.05 ± 2.65; p = 0.01) and waist circumference (99.92 vs 91.59 cm; p = 0.0001) after the treatment. Moreover, a significant decrease in serum estradiol was observed (21.23 ± 14.32 vs 16.05 ± 10.25 ng/mL; p < 0.001). The adiponectin concentration also decreased significantly (47.53 ± 12.19 vs 42.52 ± 12.34 µg/mL; p = 0.004), while IGF-1 and testosterone did not show significant changes (p > 0.05). In addition, BMI had a relationship with serum adiponectin (r = −0.27; p = 0.02) and estradiol (r = 0.37; p = 0.001).Conclusion: The current study shows that reducing BMI decreases serum estradiol and adiponectin. Large clinical trials are needed to investigate the role of adiponectin in breast cancer development in obese women. Keywords: reduced dietary fat, breast cancer, hormone levels
format	article
author	Murillo-Ortiz B Martínez-Garza S Cárdenas Landeros V Cano Velázquez G Suárez Garcia D
author_facet	Murillo-Ortiz B Martínez-Garza S Cárdenas Landeros V Cano Velázquez G Suárez Garcia D
author_sort	Murillo-Ortiz B
title	Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
title_short	Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
title_full	Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
title_fullStr	Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
title_full_unstemmed	Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer
title_sort	effect of reduced dietary fat on estradiol, adiponectin, and igf-1 levels in postmenopausal women with breast cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f52d325fea3f413fb69d767f0c123959
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Effect of reduced dietary fat on estradiol, adiponectin, and IGF-1 levels in postmenopausal women with breast cancer

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