Designing the Next Generation of Vaccines: Relevance for Future Pandemics

ABSTRACT The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the...

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Autores principales:	Jorge Domínguez-Andrés, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	vaccination metabolism epigenetics modulation trained immunity amplifier Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f52d6ed6f5fe48fa9353fec6433e0bb9
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spelling	oai:doaj.org-article:f52d6ed6f5fe48fa9353fec6433e0bb92021-11-15T15:55:44ZDesigning the Next Generation of Vaccines: Relevance for Future Pandemics10.1128/mBio.02616-202150-7511https://doaj.org/article/f52d6ed6f5fe48fa9353fec6433e0bb92020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02616-20https://doaj.org/toc/2150-7511ABSTRACT The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the immune response during vaccination has not been fully exploited. The first golden age of vaccines was based on the germ theory and the use of live, attenuated, inactivated pathogens or toxins. New strategies and formulations (e.g., adjuvants) with an immunomodulatory capacity to enhance the protective qualities and duration of vaccines have been incompletely exploited. These strategies can prevent disease and improve protection against infectious diseases, modulate the course of some noncommunicable diseases, and increase the immune responses of patients at a high risk of infection, such as the elderly or immunocompromised patients. In this minireview, we focus on how metabolic and epigenetic modulators can amplify and enhance the function of immunity in a given vaccine. We propose the term “amplifier” for such additives, and we pose that future vaccines will have three components: antigen, adjuvant, and amplifier.Jorge Domínguez-AndrésReinout van CrevelMaziar DivangahiMihai G. NeteaAmerican Society for Microbiologyarticlevaccinationmetabolismepigeneticsmodulationtrained immunityamplifierMicrobiologyQR1-502ENmBio, Vol 11, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccination metabolism epigenetics modulation trained immunity amplifier Microbiology QR1-502
spellingShingle	vaccination metabolism epigenetics modulation trained immunity amplifier Microbiology QR1-502 Jorge Domínguez-Andrés Reinout van Crevel Maziar Divangahi Mihai G. Netea Designing the Next Generation of Vaccines: Relevance for Future Pandemics
description	ABSTRACT The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the immune response during vaccination has not been fully exploited. The first golden age of vaccines was based on the germ theory and the use of live, attenuated, inactivated pathogens or toxins. New strategies and formulations (e.g., adjuvants) with an immunomodulatory capacity to enhance the protective qualities and duration of vaccines have been incompletely exploited. These strategies can prevent disease and improve protection against infectious diseases, modulate the course of some noncommunicable diseases, and increase the immune responses of patients at a high risk of infection, such as the elderly or immunocompromised patients. In this minireview, we focus on how metabolic and epigenetic modulators can amplify and enhance the function of immunity in a given vaccine. We propose the term “amplifier” for such additives, and we pose that future vaccines will have three components: antigen, adjuvant, and amplifier.
format	article
author	Jorge Domínguez-Andrés Reinout van Crevel Maziar Divangahi Mihai G. Netea
author_facet	Jorge Domínguez-Andrés Reinout van Crevel Maziar Divangahi Mihai G. Netea
author_sort	Jorge Domínguez-Andrés
title	Designing the Next Generation of Vaccines: Relevance for Future Pandemics
title_short	Designing the Next Generation of Vaccines: Relevance for Future Pandemics
title_full	Designing the Next Generation of Vaccines: Relevance for Future Pandemics
title_fullStr	Designing the Next Generation of Vaccines: Relevance for Future Pandemics
title_full_unstemmed	Designing the Next Generation of Vaccines: Relevance for Future Pandemics
title_sort	designing the next generation of vaccines: relevance for future pandemics
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/f52d6ed6f5fe48fa9353fec6433e0bb9
work_keys_str_mv	AT jorgedominguezandres designingthenextgenerationofvaccinesrelevanceforfuturepandemics AT reinoutvancrevel designingthenextgenerationofvaccinesrelevanceforfuturepandemics AT maziardivangahi designingthenextgenerationofvaccinesrelevanceforfuturepandemics AT mihaignetea designingthenextgenerationofvaccinesrelevanceforfuturepandemics
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Designing the Next Generation of Vaccines: Relevance for Future Pandemics

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