AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 and CDS2) form functional complexes that promote fur...

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Autores principales:	Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J. Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5314785099443818eeaa3ca9fffb125
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spelling	oai:doaj.org-article:f5314785099443818eeaa3ca9fffb1252021-11-28T12:32:46ZAGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway10.1038/s41467-021-27279-42041-1723https://doaj.org/article/f5314785099443818eeaa3ca9fffb1252021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27279-4https://doaj.org/toc/2041-1723AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 and CDS2) form functional complexes that promote further conversion of PA along the CDP-DAG pathway of phospholipid synthesis.Hoi Yin MakQian OuyangSergey TumanovJiesi XuPing RongFeitong DongSin Man LamXiaowei WangIvan LukmantaraXiming DuMingming GaoAndrew J. BrownXin GongGuanghou ShuiRoland StockerXun HuangShuai ChenHongyuan YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hoi Yin Mak Qian Ouyang Sergey Tumanov Jiesi Xu Ping Rong Feitong Dong Sin Man Lam Xiaowei Wang Ivan Lukmantara Ximing Du Mingming Gao Andrew J. Brown Xin Gong Guanghou Shui Roland Stocker Xun Huang Shuai Chen Hongyuan Yang AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
description	AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 and CDS2) form functional complexes that promote further conversion of PA along the CDP-DAG pathway of phospholipid synthesis.
format	article
author	Hoi Yin Mak Qian Ouyang Sergey Tumanov Jiesi Xu Ping Rong Feitong Dong Sin Man Lam Xiaowei Wang Ivan Lukmantara Ximing Du Mingming Gao Andrew J. Brown Xin Gong Guanghou Shui Roland Stocker Xun Huang Shuai Chen Hongyuan Yang
author_facet	Hoi Yin Mak Qian Ouyang Sergey Tumanov Jiesi Xu Ping Rong Feitong Dong Sin Man Lam Xiaowei Wang Ivan Lukmantara Ximing Du Mingming Gao Andrew J. Brown Xin Gong Guanghou Shui Roland Stocker Xun Huang Shuai Chen Hongyuan Yang
author_sort	Hoi Yin Mak
title	AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
title_short	AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
title_full	AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
title_fullStr	AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
title_full_unstemmed	AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
title_sort	agpat2 interaction with cdp-diacylglycerol synthases promotes the flux of fatty acids through the cdp-diacylglycerol pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5314785099443818eeaa3ca9fffb125
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AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

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