Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly

Pore-forming toxins act by forming oligomeric pores in lipid membranes. Here the authors report the crystal structure of the lysenin pore, providing insights into the assembly and function of the pore in addition to suggesting that its properties make lysenin potentially well-suited for nanopore sen...

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Autores principales:	Marjetka Podobnik, Peter Savory, Nejc Rojko, Matic Kisovec, Neil Wood, Richard Hambley, Jonathan Pugh, E. Jayne Wallace, Luke McNeill, Mark Bruce, Idlir Liko, Timothy M. Allison, Shahid Mehmood, Neval Yilmaz, Toshihide Kobayashi, Robert J. C. Gilbert, Carol V. Robinson, Lakmal Jayasinghe, Gregor Anderluh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5376f82acc44644923125077c3a3c57
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spelling	oai:doaj.org-article:f5376f82acc44644923125077c3a3c572021-12-02T14:39:13ZCrystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly10.1038/ncomms115982041-1723https://doaj.org/article/f5376f82acc44644923125077c3a3c572016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11598https://doaj.org/toc/2041-1723Pore-forming toxins act by forming oligomeric pores in lipid membranes. Here the authors report the crystal structure of the lysenin pore, providing insights into the assembly and function of the pore in addition to suggesting that its properties make lysenin potentially well-suited for nanopore sensing applications.Marjetka PodobnikPeter SavoryNejc RojkoMatic KisovecNeil WoodRichard HambleyJonathan PughE. Jayne WallaceLuke McNeillMark BruceIdlir LikoTimothy M. AllisonShahid MehmoodNeval YilmazToshihide KobayashiRobert J. C. GilbertCarol V. RobinsonLakmal JayasingheGregor AnderluhNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marjetka Podobnik Peter Savory Nejc Rojko Matic Kisovec Neil Wood Richard Hambley Jonathan Pugh E. Jayne Wallace Luke McNeill Mark Bruce Idlir Liko Timothy M. Allison Shahid Mehmood Neval Yilmaz Toshihide Kobayashi Robert J. C. Gilbert Carol V. Robinson Lakmal Jayasinghe Gregor Anderluh Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
description	Pore-forming toxins act by forming oligomeric pores in lipid membranes. Here the authors report the crystal structure of the lysenin pore, providing insights into the assembly and function of the pore in addition to suggesting that its properties make lysenin potentially well-suited for nanopore sensing applications.
format	article
author	Marjetka Podobnik Peter Savory Nejc Rojko Matic Kisovec Neil Wood Richard Hambley Jonathan Pugh E. Jayne Wallace Luke McNeill Mark Bruce Idlir Liko Timothy M. Allison Shahid Mehmood Neval Yilmaz Toshihide Kobayashi Robert J. C. Gilbert Carol V. Robinson Lakmal Jayasinghe Gregor Anderluh
author_facet	Marjetka Podobnik Peter Savory Nejc Rojko Matic Kisovec Neil Wood Richard Hambley Jonathan Pugh E. Jayne Wallace Luke McNeill Mark Bruce Idlir Liko Timothy M. Allison Shahid Mehmood Neval Yilmaz Toshihide Kobayashi Robert J. C. Gilbert Carol V. Robinson Lakmal Jayasinghe Gregor Anderluh
author_sort	Marjetka Podobnik
title	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
title_short	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
title_full	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
title_fullStr	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
title_full_unstemmed	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
title_sort	crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f5376f82acc44644923125077c3a3c57
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Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly

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