Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

B-cell encounter with antigen is thought to result in anergy, cell death, or a productive B-cell response. Here the authors show that transient antigen acquisition can enable B-cell recruitment into productive responses or a return to a naive-like state, depending on availability of T-cell help.

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Autores principales:	Jackson S. Turner, Matangi Marthi, Zachary L. Benet, Irina Grigorova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f53888cf35a4452bb69b4220e56eaacc
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spelling	oai:doaj.org-article:f53888cf35a4452bb69b4220e56eaacc2021-12-02T14:40:57ZTransiently antigen-primed B cells return to naive-like state in absence of T-cell help10.1038/ncomms150722041-1723https://doaj.org/article/f53888cf35a4452bb69b4220e56eaacc2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15072https://doaj.org/toc/2041-1723B-cell encounter with antigen is thought to result in anergy, cell death, or a productive B-cell response. Here the authors show that transient antigen acquisition can enable B-cell recruitment into productive responses or a return to a naive-like state, depending on availability of T-cell help.Jackson S. TurnerMatangi MarthiZachary L. BenetIrina GrigorovaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jackson S. Turner Matangi Marthi Zachary L. Benet Irina Grigorova Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
description	B-cell encounter with antigen is thought to result in anergy, cell death, or a productive B-cell response. Here the authors show that transient antigen acquisition can enable B-cell recruitment into productive responses or a return to a naive-like state, depending on availability of T-cell help.
format	article
author	Jackson S. Turner Matangi Marthi Zachary L. Benet Irina Grigorova
author_facet	Jackson S. Turner Matangi Marthi Zachary L. Benet Irina Grigorova
author_sort	Jackson S. Turner
title	Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
title_short	Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
title_full	Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
title_fullStr	Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
title_full_unstemmed	Transiently antigen-primed B cells return to naive-like state in absence of T-cell help
title_sort	transiently antigen-primed b cells return to naive-like state in absence of t-cell help
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f53888cf35a4452bb69b4220e56eaacc
work_keys_str_mv	AT jacksonsturner transientlyantigenprimedbcellsreturntonaivelikestateinabsenceoftcellhelp AT matangimarthi transientlyantigenprimedbcellsreturntonaivelikestateinabsenceoftcellhelp AT zacharylbenet transientlyantigenprimedbcellsreturntonaivelikestateinabsenceoftcellhelp AT irinagrigorova transientlyantigenprimedbcellsreturntonaivelikestateinabsenceoftcellhelp
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Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

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