Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

Kazuhiko Yamamuro,1 Toyosaku Ota,1 Junzo Iida,2 Yoko Nakanishi,1 Naoko Kishimoto,1 Toshifumi Kishimoto1 1Department of Psychiatry, 2Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Cognitive impairment is an important predictor of functional outcome in patients...

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Autores principales:	Yamamuro K, Ota T, Iida J, Nakanishi Y, Kishimoto N, Kishimoto T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	attention deficit/hyperactivity disorder event related potentials mismatch negativity symptom severity relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f53ab2f59c2e445e84bda3b112ffba36
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spelling	oai:doaj.org-article:f53ab2f59c2e445e84bda3b112ffba362021-12-02T04:25:36ZAssociations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder1178-2021https://doaj.org/article/f53ab2f59c2e445e84bda3b112ffba362016-12-01T00:00:00Zhttps://www.dovepress.com/associations-between-the-mismatch-negativity-component-and-symptom-sev-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kazuhiko Yamamuro,1 Toyosaku Ota,1 Junzo Iida,2 Yoko Nakanishi,1 Naoko Kishimoto,1 Toshifumi Kishimoto1 1Department of Psychiatry, 2Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Cognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology of ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment. Materials and methods: Previous studies have shown altered MMN amplitude and latency in patients with ADHD. However, little is known about the relationship between MMN and ADHD-symptom severity. To address this, we measured the amplitude and latency of MMN in ERPs and assessed correlations with the clinical severity of ADHD, as measured by the ADHD Rating Scale IV – Japanese version. Participants were 51 treatment-naïve children and adolescents with ADHD (mean age 10.42±3.35 years) and 15 normally developing age- and sex-matched children (mean age 11.8±3.36 years). Results: In the ADHD group, MMN amplitudes were attenuated at the central electrode and MMN latencies prolonged at the parietal electrode (Pz) relative to those in the control group. Furthermore, MMN amplitudes at Pz were negatively correlated with ADHD full-scale and hyperactivity–impulsivity and inattention subscale scores, and MMN latency at Pz was positively correlated with ADHD hyperactivity–impulsivity subscale scores. Conclusion: Our data suggest that MMN reflects the severity of ADHD symptoms in children and adolescents, and provides support for the use of ERPs in evaluating ADHD symptoms in patients. Keywords: attention deficit/hyperactivity disorder, event-related potentials, mismatch negativity, symptom severity, relationshipYamamuro KOta TIida JNakanishi YKishimoto NKishimoto TDove Medical Pressarticleattention deficit/hyperactivity disorderevent related potentialsmismatch negativitysymptom severityrelationshipNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3183-3190 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	attention deficit/hyperactivity disorder event related potentials mismatch negativity symptom severity relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	attention deficit/hyperactivity disorder event related potentials mismatch negativity symptom severity relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yamamuro K Ota T Iida J Nakanishi Y Kishimoto N Kishimoto T Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
description	Kazuhiko Yamamuro,1 Toyosaku Ota,1 Junzo Iida,2 Yoko Nakanishi,1 Naoko Kishimoto,1 Toshifumi Kishimoto1 1Department of Psychiatry, 2Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Cognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology of ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment. Materials and methods: Previous studies have shown altered MMN amplitude and latency in patients with ADHD. However, little is known about the relationship between MMN and ADHD-symptom severity. To address this, we measured the amplitude and latency of MMN in ERPs and assessed correlations with the clinical severity of ADHD, as measured by the ADHD Rating Scale IV – Japanese version. Participants were 51 treatment-naïve children and adolescents with ADHD (mean age 10.42±3.35 years) and 15 normally developing age- and sex-matched children (mean age 11.8±3.36 years). Results: In the ADHD group, MMN amplitudes were attenuated at the central electrode and MMN latencies prolonged at the parietal electrode (Pz) relative to those in the control group. Furthermore, MMN amplitudes at Pz were negatively correlated with ADHD full-scale and hyperactivity–impulsivity and inattention subscale scores, and MMN latency at Pz was positively correlated with ADHD hyperactivity–impulsivity subscale scores. Conclusion: Our data suggest that MMN reflects the severity of ADHD symptoms in children and adolescents, and provides support for the use of ERPs in evaluating ADHD symptoms in patients. Keywords: attention deficit/hyperactivity disorder, event-related potentials, mismatch negativity, symptom severity, relationship
format	article
author	Yamamuro K Ota T Iida J Nakanishi Y Kishimoto N Kishimoto T
author_facet	Yamamuro K Ota T Iida J Nakanishi Y Kishimoto N Kishimoto T
author_sort	Yamamuro K
title	Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
title_short	Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
title_full	Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
title_fullStr	Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
title_full_unstemmed	Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
title_sort	associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f53ab2f59c2e445e84bda3b112ffba36
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Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

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