Minimally disruptive optical control of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.

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Auteurs principaux: Akarawin Hongdusit, Peter H. Zwart, Banumathi Sankaran, Jerome M. Fox
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca
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Résumé:Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.