Minimally disruptive optical control of protein tyrosine phosphatase 1B
Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.
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Nature Portfolio
2020
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oai:doaj.org-article:f53b098dc10846f9bfe2b508a3bcd5ca2021-12-02T17:33:15ZMinimally disruptive optical control of protein tyrosine phosphatase 1B10.1038/s41467-020-14567-82041-1723https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14567-8https://doaj.org/toc/2041-1723Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.Akarawin HongdusitPeter H. ZwartBanumathi SankaranJerome M. FoxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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Science Q Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox Minimally disruptive optical control of protein tyrosine phosphatase 1B |
description |
Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization. |
format |
article |
author |
Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox |
author_facet |
Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox |
author_sort |
Akarawin Hongdusit |
title |
Minimally disruptive optical control of protein tyrosine phosphatase 1B |
title_short |
Minimally disruptive optical control of protein tyrosine phosphatase 1B |
title_full |
Minimally disruptive optical control of protein tyrosine phosphatase 1B |
title_fullStr |
Minimally disruptive optical control of protein tyrosine phosphatase 1B |
title_full_unstemmed |
Minimally disruptive optical control of protein tyrosine phosphatase 1B |
title_sort |
minimally disruptive optical control of protein tyrosine phosphatase 1b |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca |
work_keys_str_mv |
AT akarawinhongdusit minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT peterhzwart minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT banumathisankaran minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT jeromemfox minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b |
_version_ |
1718380036781768704 |