Minimally disruptive optical control of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.

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Bibliographic Details
Main Authors:	Akarawin Hongdusit, Peter H. Zwart, Banumathi Sankaran, Jerome M. Fox
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca
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spelling	oai:doaj.org-article:f53b098dc10846f9bfe2b508a3bcd5ca2021-12-02T17:33:15ZMinimally disruptive optical control of protein tyrosine phosphatase 1B10.1038/s41467-020-14567-82041-1723https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14567-8https://doaj.org/toc/2041-1723Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.Akarawin HongdusitPeter H. ZwartBanumathi SankaranJerome M. FoxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox Minimally disruptive optical control of protein tyrosine phosphatase 1B
description	Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.
format	article
author	Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox
author_facet	Akarawin Hongdusit Peter H. Zwart Banumathi Sankaran Jerome M. Fox
author_sort	Akarawin Hongdusit
title	Minimally disruptive optical control of protein tyrosine phosphatase 1B
title_short	Minimally disruptive optical control of protein tyrosine phosphatase 1B
title_full	Minimally disruptive optical control of protein tyrosine phosphatase 1B
title_fullStr	Minimally disruptive optical control of protein tyrosine phosphatase 1B
title_full_unstemmed	Minimally disruptive optical control of protein tyrosine phosphatase 1B
title_sort	minimally disruptive optical control of protein tyrosine phosphatase 1b
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f53b098dc10846f9bfe2b508a3bcd5ca
work_keys_str_mv	AT akarawinhongdusit minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT peterhzwart minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT banumathisankaran minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b AT jeromemfox minimallydisruptiveopticalcontrolofproteintyrosinephosphatase1b
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Minimally disruptive optical control of protein tyrosine phosphatase 1B

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