Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma

Background:Bronchial asthma is a chronic airway disease. Cardiac affection in children with bronchial asthma was reported mainly in cases with severe asthma and during acute exacerbations. Aim of the Work:To study cardiac affection in children with mild and moderate bronchial asthma using convention...

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Autores principales:	Tarek Kotb Alsayad, Saad Ahmed Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	bronchial asthma children ventricular function tissue doppler imaging pulmonary artery pressure Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f53e16c9151c4afe81c6cb208757dc07
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spelling	oai:doaj.org-article:f53e16c9151c4afe81c6cb208757dc072021-12-02T17:05:59ZVentricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma2636-41742682-378010.21608/ijma.2021.187835https://doaj.org/article/f53e16c9151c4afe81c6cb208757dc072021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_187835_9b7c75fba11fd712f287a75a30d5cd9b.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background:Bronchial asthma is a chronic airway disease. Cardiac affection in children with bronchial asthma was reported mainly in cases with severe asthma and during acute exacerbations. Aim of the Work:To study cardiac affection in children with mild and moderate bronchial asthma using conventional and tissue Doppler imaging [TDI] echocardiography. Patients and Methods:This was a prospective case control study. Study involved 160 children aged 6-14 years’ old who were following in outpatient pediatric clinic, Al-Hussein hospital, Al-Azhar University, Cairo, Egypt, during the period from January 4, 2016, till February 15, 2017. All children underwent peak expiratory flow rate [PEFR] assessment. Echocardiography was done for all to assess systolic and diastolic functions of right ventricle [RV] and left ventricle [LV] using conventional and tissue Doppler imaging [TDI] echocardiography Results:TDI parameters showed evidence of RV diastolic dysfunction in patients with moderate asthma in the form of significantly lower tricuspid valve [TV] e’ [12.1 ± 2.7 cm/s], lower TV e’/a’ ratio [1.28 ± 0.18], prolonged RV isovolumetric relaxation time [IVRT] [71.8 ± 2.4 ms], and higher RV myocardial performance index [0.49 ± 0.04] compared to control group. Also, patients with mild asthma had impaired RV diastolic function in the form of significantly lower TV e’/a’ [1.51 ± 0.13] and longer RV IVRT [65 ± 2.9 ms] compared to control group. Pulmonary artery pressure was significantly elevated in moderate asthma group [18.4 ± 9.2 mmHg]. RV IVRT was the only parameter showing a significant negative correlation to PEFR Conclusion: Pediatric patients with mild and moderate bronchial asthma may have RV diastolic dysfunction. TDI is a good screening tool to detect early changes in cardiac function in such patients. RV IVRT measured by TDI is a sensitive tool to detect early diastolic impairment.Tarek Kotb AlsayadSaad Ahmed MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlebronchial asthmachildrenventricular functiontissue doppler imagingpulmonary artery pressureMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1754-1760 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchial asthma children ventricular function tissue doppler imaging pulmonary artery pressure Medicine (General) R5-920
spellingShingle	bronchial asthma children ventricular function tissue doppler imaging pulmonary artery pressure Medicine (General) R5-920 Tarek Kotb Alsayad Saad Ahmed Mohamed Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
description	Background:Bronchial asthma is a chronic airway disease. Cardiac affection in children with bronchial asthma was reported mainly in cases with severe asthma and during acute exacerbations. Aim of the Work:To study cardiac affection in children with mild and moderate bronchial asthma using conventional and tissue Doppler imaging [TDI] echocardiography. Patients and Methods:This was a prospective case control study. Study involved 160 children aged 6-14 years’ old who were following in outpatient pediatric clinic, Al-Hussein hospital, Al-Azhar University, Cairo, Egypt, during the period from January 4, 2016, till February 15, 2017. All children underwent peak expiratory flow rate [PEFR] assessment. Echocardiography was done for all to assess systolic and diastolic functions of right ventricle [RV] and left ventricle [LV] using conventional and tissue Doppler imaging [TDI] echocardiography Results:TDI parameters showed evidence of RV diastolic dysfunction in patients with moderate asthma in the form of significantly lower tricuspid valve [TV] e’ [12.1 ± 2.7 cm/s], lower TV e’/a’ ratio [1.28 ± 0.18], prolonged RV isovolumetric relaxation time [IVRT] [71.8 ± 2.4 ms], and higher RV myocardial performance index [0.49 ± 0.04] compared to control group. Also, patients with mild asthma had impaired RV diastolic function in the form of significantly lower TV e’/a’ [1.51 ± 0.13] and longer RV IVRT [65 ± 2.9 ms] compared to control group. Pulmonary artery pressure was significantly elevated in moderate asthma group [18.4 ± 9.2 mmHg]. RV IVRT was the only parameter showing a significant negative correlation to PEFR Conclusion: Pediatric patients with mild and moderate bronchial asthma may have RV diastolic dysfunction. TDI is a good screening tool to detect early changes in cardiac function in such patients. RV IVRT measured by TDI is a sensitive tool to detect early diastolic impairment.
format	article
author	Tarek Kotb Alsayad Saad Ahmed Mohamed
author_facet	Tarek Kotb Alsayad Saad Ahmed Mohamed
author_sort	Tarek Kotb Alsayad
title	Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
title_short	Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
title_full	Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
title_fullStr	Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
title_full_unstemmed	Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma
title_sort	ventricular function and pulmonary artery pressure in children with mild and moderate bronchial asthma
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/f53e16c9151c4afe81c6cb208757dc07
work_keys_str_mv	AT tarekkotbalsayad ventricularfunctionandpulmonaryarterypressureinchildrenwithmildandmoderatebronchialasthma AT saadahmedmohamed ventricularfunctionandpulmonaryarterypressureinchildrenwithmildandmoderatebronchialasthma
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Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma

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