Advances in drug delivery via electrospun and electrosprayed nanomaterials

Maedeh Zamani,1 Molamma P Prabhakaran,2 Seeram Ramakrishna1,21Department of Mechanical Engineering, 2Center for Nanofibers and Nanotechnology, National University of Singapore, SingaporeAbstract: Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate...

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Autores principales:	Zamani M, Prabhakaran MP, Ramakrishna S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f53ebe0e596141e8b406e39ea9b81ff7
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spelling	oai:doaj.org-article:f53ebe0e596141e8b406e39ea9b81ff72021-12-02T08:06:26ZAdvances in drug delivery via electrospun and electrosprayed nanomaterials1176-91141178-2013https://doaj.org/article/f53ebe0e596141e8b406e39ea9b81ff72013-08-01T00:00:00Zhttp://www.dovepress.com/advances-in-drug-delivery-via-electrospun-and-electrosprayed-nanomater-a13985https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Maedeh Zamani,1 Molamma P Prabhakaran,2 Seeram Ramakrishna1,21Department of Mechanical Engineering, 2Center for Nanofibers and Nanotechnology, National University of Singapore, SingaporeAbstract: Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.Keywords: electrospinning, electrospraying, gene delivery, growth-factor delivery, cancer therapy, wound dressingZamani MPrabhakaran MPRamakrishna SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2997-3017 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zamani M Prabhakaran MP Ramakrishna S Advances in drug delivery via electrospun and electrosprayed nanomaterials
description	Maedeh Zamani,1 Molamma P Prabhakaran,2 Seeram Ramakrishna1,21Department of Mechanical Engineering, 2Center for Nanofibers and Nanotechnology, National University of Singapore, SingaporeAbstract: Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.Keywords: electrospinning, electrospraying, gene delivery, growth-factor delivery, cancer therapy, wound dressing
format	article
author	Zamani M Prabhakaran MP Ramakrishna S
author_facet	Zamani M Prabhakaran MP Ramakrishna S
author_sort	Zamani M
title	Advances in drug delivery via electrospun and electrosprayed nanomaterials
title_short	Advances in drug delivery via electrospun and electrosprayed nanomaterials
title_full	Advances in drug delivery via electrospun and electrosprayed nanomaterials
title_fullStr	Advances in drug delivery via electrospun and electrosprayed nanomaterials
title_full_unstemmed	Advances in drug delivery via electrospun and electrosprayed nanomaterials
title_sort	advances in drug delivery via electrospun and electrosprayed nanomaterials
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f53ebe0e596141e8b406e39ea9b81ff7
work_keys_str_mv	AT zamanim advancesindrugdeliveryviaelectrospunandelectrosprayednanomaterials AT prabhakaranmp advancesindrugdeliveryviaelectrospunandelectrosprayednanomaterials AT ramakrishnas advancesindrugdeliveryviaelectrospunandelectrosprayednanomaterials
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Advances in drug delivery via electrospun and electrosprayed nanomaterials

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