Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Abstract Renal diseases impose considerable health and economic burdens on health systems worldwide, and there is a lack of efficient methods for the prevention and treatment due to their complexity and heterogeneity. Kidneys are organs with a high demand for energy produced by mitochondria, in whic...

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Autores principales:	Yi-Fan Chen, I-Hsuan Lin, Yu-Ru Guo, Wei-Jun Chiu, Mai-Szu Wu, Wei Jia, Yun Yen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f53ecd6e0971403ab1d3fc73940a2606
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spelling	oai:doaj.org-article:f53ecd6e0971403ab1d3fc73940a26062021-12-02T15:09:15ZRrm2b deletion causes mitochondrial metabolic defects in renal tubules10.1038/s41598-019-49663-32045-2322https://doaj.org/article/f53ecd6e0971403ab1d3fc73940a26062019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49663-3https://doaj.org/toc/2045-2322Abstract Renal diseases impose considerable health and economic burdens on health systems worldwide, and there is a lack of efficient methods for the prevention and treatment due to their complexity and heterogeneity. Kidneys are organs with a high demand for energy produced by mitochondria, in which Rrm2b has critical functions as reported. The Rrm2b kidney-specific knockout mice we generated exhibited age-dependent exacerbated features, including mitochondrial dysfunction and increased oxidative stress; additionally, resulted in severe disruption of mitochondria-related metabolism. Rrm2b is vital not only to supply dNTPs for DNA replication and repair, but also to maintain structural integrity and metabolic homeostasis in mitochondria. Thence, Rrm2b deletion might induce chronic kidney defects in mice. This model can facilitate exploration of novel mechanisms and targeted therapies in the kidney diseases and has important translational and clinical implications.Yi-Fan ChenI-Hsuan LinYu-Ru GuoWei-Jun ChiuMai-Szu WuWei JiaYun YenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Fan Chen I-Hsuan Lin Yu-Ru Guo Wei-Jun Chiu Mai-Szu Wu Wei Jia Yun Yen Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
description	Abstract Renal diseases impose considerable health and economic burdens on health systems worldwide, and there is a lack of efficient methods for the prevention and treatment due to their complexity and heterogeneity. Kidneys are organs with a high demand for energy produced by mitochondria, in which Rrm2b has critical functions as reported. The Rrm2b kidney-specific knockout mice we generated exhibited age-dependent exacerbated features, including mitochondrial dysfunction and increased oxidative stress; additionally, resulted in severe disruption of mitochondria-related metabolism. Rrm2b is vital not only to supply dNTPs for DNA replication and repair, but also to maintain structural integrity and metabolic homeostasis in mitochondria. Thence, Rrm2b deletion might induce chronic kidney defects in mice. This model can facilitate exploration of novel mechanisms and targeted therapies in the kidney diseases and has important translational and clinical implications.
format	article
author	Yi-Fan Chen I-Hsuan Lin Yu-Ru Guo Wei-Jun Chiu Mai-Szu Wu Wei Jia Yun Yen
author_facet	Yi-Fan Chen I-Hsuan Lin Yu-Ru Guo Wei-Jun Chiu Mai-Szu Wu Wei Jia Yun Yen
author_sort	Yi-Fan Chen
title	Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
title_short	Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
title_full	Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
title_fullStr	Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
title_full_unstemmed	Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
title_sort	rrm2b deletion causes mitochondrial metabolic defects in renal tubules
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f53ecd6e0971403ab1d3fc73940a2606
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_version_	1718387913771712512

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

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