A review of the resistome within the digestive tract of livestock

Abstract Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production animals. However, the occurrence of antimicrobial resistance poses a huge threat to public and animal health, especially in less developed countries where food-producing anima...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tao Ma, Tim A. McAllister, Le Luo Guan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Antimicrobial resistance Antimicrobial resistance gene Digestive tract, Food-producing animal Metagenomic sequencing Resistome Animal culture SF1-1100 Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/f5435bd2a455445a878785a90b807575
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f5435bd2a455445a878785a90b807575
record_format	dspace
spelling	oai:doaj.org-article:f5435bd2a455445a878785a90b8075752021-11-14T12:33:11ZA review of the resistome within the digestive tract of livestock10.1186/s40104-021-00643-62049-1891https://doaj.org/article/f5435bd2a455445a878785a90b8075752021-11-01T00:00:00Zhttps://doi.org/10.1186/s40104-021-00643-6https://doaj.org/toc/2049-1891Abstract Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production animals. However, the occurrence of antimicrobial resistance poses a huge threat to public and animal health, especially in less developed countries where food-producing animals often intermingle with humans. To limit the spread of antimicrobial resistance from food-production animals to humans and the environment, it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance (AMR), The resistome refers to the collection of all antimicrobial resistance genes associated with microbiota in a given environment. The dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in nature. Studies of the resistome in the digestive tract of humans and animals are increasing exponentially as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the resistome. In this review, we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine, poultry, and ruminants. We then propose future research directions including analysis of resistome using long-read sequencing, investigation in the role of mobile genetic elements in the expression, function and transmission of AMR. This review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems.Tao MaTim A. McAllisterLe Luo GuanBMCarticleAntimicrobial resistanceAntimicrobial resistance geneDigestive tract, Food-producing animalMetagenomic sequencingResistomeAnimal cultureSF1-1100Veterinary medicineSF600-1100ENJournal of Animal Science and Biotechnology, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimicrobial resistance Antimicrobial resistance gene Digestive tract, Food-producing animal Metagenomic sequencing Resistome Animal culture SF1-1100 Veterinary medicine SF600-1100
spellingShingle	Antimicrobial resistance Antimicrobial resistance gene Digestive tract, Food-producing animal Metagenomic sequencing Resistome Animal culture SF1-1100 Veterinary medicine SF600-1100 Tao Ma Tim A. McAllister Le Luo Guan A review of the resistome within the digestive tract of livestock
description	Abstract Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production animals. However, the occurrence of antimicrobial resistance poses a huge threat to public and animal health, especially in less developed countries where food-producing animals often intermingle with humans. To limit the spread of antimicrobial resistance from food-production animals to humans and the environment, it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance (AMR), The resistome refers to the collection of all antimicrobial resistance genes associated with microbiota in a given environment. The dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in nature. Studies of the resistome in the digestive tract of humans and animals are increasing exponentially as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the resistome. In this review, we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine, poultry, and ruminants. We then propose future research directions including analysis of resistome using long-read sequencing, investigation in the role of mobile genetic elements in the expression, function and transmission of AMR. This review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems.
format	article
author	Tao Ma Tim A. McAllister Le Luo Guan
author_facet	Tao Ma Tim A. McAllister Le Luo Guan
author_sort	Tao Ma
title	A review of the resistome within the digestive tract of livestock
title_short	A review of the resistome within the digestive tract of livestock
title_full	A review of the resistome within the digestive tract of livestock
title_fullStr	A review of the resistome within the digestive tract of livestock
title_full_unstemmed	A review of the resistome within the digestive tract of livestock
title_sort	review of the resistome within the digestive tract of livestock
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f5435bd2a455445a878785a90b807575
work_keys_str_mv	AT taoma areviewoftheresistomewithinthedigestivetractoflivestock AT timamcallister areviewoftheresistomewithinthedigestivetractoflivestock AT leluoguan areviewoftheresistomewithinthedigestivetractoflivestock AT taoma reviewoftheresistomewithinthedigestivetractoflivestock AT timamcallister reviewoftheresistomewithinthedigestivetractoflivestock AT leluoguan reviewoftheresistomewithinthedigestivetractoflivestock
_version_	1718429203904331776

A review of the resistome within the digestive tract of livestock

Ejemplares similares